نتایج جستجو برای: dysbindin
تعداد نتایج: 182 فیلتر نتایج به سال:
CONTEXT Association studies in bipolar disorder have been focused on a relatively narrow pool of candidate genes based on a limited understanding of the underlying pathophysiologic features. Recent developments suggest that a broader pool of genes may be associated with this disorder. OBJECTIVE To examine the association between genes related to the lithium mechanism of action, as well as oth...
BACKGROUND Despite the substantial heritability of the psychoses and their genuine public health burden, the applicability of the genomic approach in psychiatry has been strongly questioned or prematurely dismissed. METHODS selective review of the recent literature on molecular genetic and genomic approaches to the psychoses including the early output from genome-wide association studies and ...
OBJECTIVES Dysbindin (DTNBP1) has been identified as a susceptibility gene for schizophrenia (SZ) through a positional approach. However, a variety of single nucleotide polymorphisms (SNPs) and haplotypes, in different parts of the gene, have been reported to be associated in different samples, and a precise molecular mechanism of disease remains to be defined. We have performed an association ...
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