It has been generally recognized that human growth hormone (HGH) has the effect to facilitate growth in cases of pituitary dwarfism. As of April 1970, however, there are only 33 reported cases in the world in which HGH has been administered for more than two years (Soyka et al., 1970). We have treated 14 cases of pituitary dwarfism with HGH, and observed initial increases in growth rate in all ...

A case of a 14-year-old boy with optic hypoplasia and pituitary dwarfism was presented. Eye Examination showed typical hypoplasia of the left optic nerve and mild hypoplasia of the right optic nerve. Except for dwarfism and nystagmus, the appearance of the patient was not unusual. Computed tomography revealed an enlargement of the suprachiasmatic cistern, and the presence of the septum pellucid...

A 29-year-old multipara presented at the University Hospital, Kuala Lumpur at 26 weeks gestation. She has had two normal deliveries at this hospital, a girl in 1977 and a boy in 1978. Both children are normal and healthy. In this third pregnancy uterine size was larger than dates and hydramnios was suspected. Sonography confirmed the hydramnios and showed a single foetus with hydrocephalus and ...

Osteochondrodysplasias are caused by abnormal development and growth of cartilage and bone. These abnormalities have been reported in both humans and animals with dwarfism. The basset hound is considered a breed with a disproportionate prevalence of dwarfism, the cause of which is unknown. To determine the type of osteochondrodysplasia in this breed, we analyzed histologically the growth plates...

PURPOSE OF THE REVIEW This review will provide an overview of the microcephalic primordial dwarfism (MPD) class of disorders and provide the reader comprehensive clinical review with suggested care guidelines for patients with microcephalic osteodysplastic primordial dwarfism, type II (MOPDII). RECENT FINDINGS Over the last 15 years, significant strides have been made in the diagnosis, natura...

Achondroplasia is the most frequent of more than 100 described types of skeletal dysplasia which lead to dwarfism. The incidence is approx. 0.5-1.5 in 10,000 newborns [1]. Spontaneous mutations cause up to 80% of the diseases. Hereditary propagation takes place in terms of autosomal-dominant transmission. Females are more often affected than males [13,19,22]. Genetically speaking, this is the m...