Most discussions about the aetiology of duodenal ulcer depict the duodenal bulb as a battlefield, on which aggressive and defensive factors wage a continuous and continuing campaign for the integrity of the bulbar mucosa. When the scales are tipped in favour of aggression, an ulcer develops. The battlefield is unique, because it is chemical warfare that is usually thought to be taking place hen...

Recent studies have reported the association of a pro-inflammatory profile of genetic polymorphisms in IL-1B, IL-1RN, TNF-A, and IL-10 genes with an increased risk of non-cardia gastric cancer. Because gastric cancer and duodenal ulcer are mutually exclusive outcomes of Helicobacter pylori infection, we aimed to investigate possible allelic variant associations of several functional polymorphis...

This study examines the relationship between Helicobacter pylori infection and peptic ulcer disease and gastric cancer--in particular, the presence or absence of bacteria, the grading of gastritis, and the degree of inflammation in the antral and oxyntic mucosae. The grading of gastritis and the detection of H pylori were determined by histology using the Sydney system. Of the 1006 patients exa...

BACKGROUND Duodenal ulcer perforations are a common surgical emergency, but literature is silent on the exact definition, incidence, management and complications of large perforations of duodenal ulcers. METHODS The case files of 162 patients who underwent emergency laparotomy for duodenal ulcer perforations over a period of three years (2001 - 2003) were retrospectively reviewed and sorted i...

The present paper compares the temporal changes of cigarette consumption with those of peptic ulcer mortality in the United Kingdom. Cumulative cigarette consumption increased in men born between 1845 and 1915 and remained constant or decreased in all subsequent generations. It increased in women born between 1835 and 1955. In contrast, both male and female mortality from gastric and duodenal u...

BACKGROUND Studies assessing the efficacy of triple therapy containing clarithromycin and amoxicillin for the eradication of Helicobacter pylori infection and healing of duodenal ulcers in Asian and African countries are limited. AIM To determine the efficacy and safety of 1-week triple therapy with omeprazole, amoxicillin and clarithromycin for eradicating H. pylori infection in patients wit...

Duodenogastric reflux of bile acids and lysolecithin in the course of a standard test meal was measured in normal people and in patients with duodenal ulcer before operation and more than one year after highly selective vagotomy, Polya partial gastrectomy, truncal vagotomy and pyloroplasty, and truncal vagotomy and gastrojejunostomy. Before operation, duodenal ulcer patients had significantly h...

The following case of perforated duodenal ulcer in an infant is reported, not only on account of the raritv of the condition, but also because the symptoms and course presented differ somewhat from those in previouslv reported cases. Peptic ulcers are evidently not very rare in infants under one year of age, but onlv a few have been recorded in England. In Welch's1 collection of 6074 cases of p...

Recent studies by Wormsley and Mahony (1967) and by Banks, Dyck, Dreiling, and Janowitz (1967) have shown that the ratio between the secretory capacity of pancreatic bicarbonate and gastric acid is lower in duodenal ulcer patients than in normal subjects. It has therefore been suggested (Wormsley and Mahony, 1967; Rovelstad, 1956) that duodenal neutralization is insufficient in this disease. So...

To assess the healing and relapse rate of duodenal ulcer (DU) treated with H2 receptor antagonists in helicobacter pylori (HP) positive vs negative cases, we analysed 95 cases of endoscopically proven duodenal ulcer. H. pylori colonization was found in 73 (77%) patients before treatment. No difference was observed in the pre-treatment characteristics between patients with HP positive and HP neg...