STUDY OBJECTIVES The purpose of this study was to investigate the effect of heavy-ion radiotherapy on pulmonary function in patients with clinical stage I non-small cell lung cancer (NSCLC) patients. DESIGN Retrospective study. SETTING Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan. PATIENTS From a total of 81 patients who ...

OBJECTIVES Several cases of syndrome of inappropriate antidiuresis induced by anti-Parkinson agents have been reported. Our previous study demonstrated that pergolide and pramipexole stimulated elevation of plasma arginine vasopressin (AVP) levels in some patients with Parkinson's disease (PD), but that levodopa/carbidopa (300/30 mg/day) did not affect plasma AVP levels in treatment-naïve PD pa...

The aim of the present study was to formulate lornoxicam into rectal suppositories as a new dosage form, to avoid its reported gastric irritation and to provide a rapid onset of action for children. Suppositories were prepared using fatty bases namely; witepsol H-15, suppocire AML, CM, witepsol E-75 and water soluble bases; mixtures of poly(ethylene glycol), PEGs, with different molecular weigh...

The glucagon-like peptide 1 (GLP-1) analog ROSE-010 reduced pain during acute exacerbations of irritable bowel syndrome (IBS). Our objective was to assess effects of ROSE-010 on several gastrointestinal (GI) motor and bowel functions in constipation-predominant IBS (IBS-C). In a single-center, randomized, parallel-group, double-blind, placebo-controlled, dose-response study, we evaluated safety...

The purpose of in-vitro chromosome aberration assay (ABS) is to determine whether the test compound is a clastogen which induces structural changes in chromosomes. The ABS belongs to the standard three test battery for genotoxicity testing for pharmaceuticals recommended by the fourth International Conference on Harmonisation (1997, Brussel). A full account of biological details of this assay c...

calcium hydroxide is the most widely used intracanal medicament in endodontics, which should be removed prior to permanent root canal filling to minimize its intervention with the bonding of endodontic sealers. this ex-vivo study aimed to evaluate the effect of pretreatment with calcium hydroxide on the bond strength of resilon/epiphany self etch (se) to the radicular dentin after removing the ...

this study investigates the relationship between litter quality and aerial parts of plant on c, n, k, p and c/n ratio of soil in four rangeland species including agropyron intermedium, bromus tomentellus, eurotia ceratoides and kochia prostrata. after recognizing the sites of these species in hamand absard located in 65 km of northern tehran, at the end of growing season, samples of litter, aer...