Recent experience has prompted the US FDA to consider whether ethanol ingestion may modify the release characteristics of prolonged-release formulations, where dose dumping may be an issue for patient safety. The influence of ethanol on the in vitro release of opioid drugs from some prolonged-release formulations utilizing different release technologies was examined. Results indicated that the ...

The historical development of thermodynamics follows the industrial revolution in the 19 century, and the advent of heat engines. It is interesting to see how such practical considerations as the efficiency of engines can lead to abstract ideas like entropy. An idealized heat engine works by taking in a certain amount of heat QH , from a heat source (for example a coal fire), converting a porti...

The paper aims to mapping the potential vulnerable areas to illegal dumping of household waste from rural areas in the extraCarpathian region of Neamț County. These areas are ordinary in the proximity of built-up areas and buffers areas of 1km were delimited for every locality. Based on various map layers in vector formats ( land use, rivers, buil-up areas, roads etc) an assessment method is pe...

Business representatives and union leaders in highly industrialised countries often accuse the governments of lessdeveloped countries of practising social dumping in the sense of deliberately neglecting work-place safety legislation, codetermination rights and other fringe benefits which define the quality of workplaces. This paper refutes this view by modelling the transition path of a less-de...

We analyze a rationale for official authorization of patient dumping in the prospective payment policy framework. We show that when the insurer designs the healthcare payment policy to let hospitals dump high-cost patients, there is a trade-off between the disutility of dumped patients (changes in hospitals' rent extraction due to low-severity patients) and the shift in the level of cost reduct...

Standardization of metagenomic DNA extraction protocol is a pre-requisite for a successful metagenomic study aiming to screen and exploit the variety of microorganisms inhabiting a particular soil environment. Six methods reported earlier were used for isolation of metagenomic DNA in the present study. These methods suffered with regard to either poor yield or quality of DNA. Therefore, we deve...

In a three-country oligopoly model, this paper analyzes two countries’ decisions concerning antidumping (AD) action against each other and the relationship between those decisions and the countries’ RTAs with the third-country. An RTA intensifies product-market competition in the domestic market and lowers product prices. This effect widens the dumping margin of the foreign firm and narrows the...

The Android operating system for mobile phones, which is still relatively new, is rapidly gaining market share, with dozens of smartphones and tablets either released or set to be released. In this paper, we present the first methodology and toolset for acquisition and deep analysis of volatile physical memory from Android devices. The paper discusses some of the challenges in performing Androi...