Chromatin insulators/boundary elements share the ability to insulate a transgene from its chromosomal context by blocking promiscuous enhancer-promoter interactions and heterochromatin spreading. Several insulating factors target different DNA consensus sequences, defining distinct subfamilies of insulators. Whether each of these families and factors might possess unique cellular functions is o...

Binary Factor Analysis (BFA) is a typical problem of Independent Component Analysis (ICA) where the signal sources are binary. Parameter learning and model selection in BFA are computationally intractable because of the combinatorial complexity. This paper aims at an efficient approach to BFA. For parameter learning, an unconstrained binary quadratic programming (BQP) is reduced to a canonical ...

Ischemic brain injury involves a complex sequence of excitetoxic and oxidative events. Metformin is proposed as one of the potential candidates for returning the body to its basic homeostasis in ischemic situations. Metformin can either protect or damage cells by activating AMP-activated protein kinase (AMPK) and its downstream factors so, it has a dual role in the cerebral ischemia context, bu...

A new multi-layer substrate integrated waveguide (SIW) structure is developed to design dual-band evanescent-mode band-pass filters (BPFs). Two independent series LC circuits are implemented by incorporating metallic irises in the different layers of the structure. The combination of the metallic irises with capacitive-plates is embedded inside the SIW to independently excite two evane...

We introduce the local field interaction approach to Dirac magnetic monopoles. Our analysis reveals two physically different types of a monopole. The first type is free singularity, and angular momentum plays an essential role in interaction. second described as endpoint invisible semi-infinite flux tube (a string). Notably, phase factor exists between where n quantum number momentum. study pro...

IFNγ (interferon γ ), a cytokine typically secreted by infiltrating immune cells in insulitis in Type 1 diabetes, is by itself not detrimental to β-cells, but, together with other cytokines, such as IL-1β (interleukin 1β) and TNFα (tumour necrosis factor α), or dsRNA (double-stranded RNA), it induces β-cell apoptosis. The complex gene and protein networks that are altered by the combination of ...