Low molecular weight heparin (LMWH) exhibits anti-inflammatory properties, but its effect on inflammation in colitis remains unclear. This study aimed to evaluate the therapeutic effects of LMWH on dextran sulfate sodium (DSS)-induced colitis in mice, in which acute colitis progresses to chronic colitis, and to explore the potential mechanism involved in this process. C57BL/6 mice were randomly...

The netrin-1 administration or overexpression is known to protect colon from acute colitis. However, the receptor that mediates netrin-1 protective activities in the colon during colitis remains unknown. We tested the hypothesis that UNC5B receptor is a critical mediator of protective function of netrin-1 in dextran sodium sulfate (DSS)-induced colitis using mice with partial deletion of UNC5B ...

The impact of the dietary protein level on the process of colonic mucosal inflammation and subsequent recovery remains largely unknown. In this study, we fed DSS-treated mice with either a normoproteic (NP) or a high-protein (HP) isocaloric diet from the beginning of the 5-day dextran sulfate sodium (DSS) treatment to 14 days later. Measurements of colitis indicators (colon weight:length ratio,...

The microbiota affects host health, and dysbiosis is involved in colitis. Sorghum bran influences butyrate concentrations during dextran sodium sulfate (DSS) colitis, suggesting microbiota changes. We aimed to characterize the microbiota during colitis, and ascertain if polyphenol-rich sorghum bran diets mitigate these effects. Rats (n = 80) were fed diets containing 6% fiber from cellulose, or...

computer-integrated manufacturing (cim), technologies are presented as solutions tomanufacturing organizations, which need to perform well in all customer-related dimensionssimultaneously. in the literature, cim technologies providing such benefits as more frequentproduction changes, reduced inventory level, improved ability of producing complex parts with ahigh degree of accuracy and repeatabi...

Abstract In this analysis, corrosion efficiency and mechanical properties of duplex stainless steel castings (DSS-4A DSS-5A) were compared to their wrought counterparts. Cast DSS-4A DSS-5A are characterized in two separate solution treated settings, while counterparts both solutions forged form. Optical microscopy X-ray diffractometry employed perform the metallurgical characterization. Electro...

Difference Systems of Sets (DSS) are combinatorial configurations that arise in connection with code synchronization. This paper gives new constructions of DSS obtained from partitions of hyperplanes in a finite projective space, as well as DSS obtained from balanced generalized weighing matrices and partitions of the complement of a hyperplane in a finite projective space. ∗Research supported ...

Dextran sodium sulfate (DSS)-induced colitis is widely used to study pathological mechanisms and potential treatments of inflammatory bowel disease. Because temporal changes in genome expression profiles remain unknown in this model, we performed whole genome expression profile analysis during the development of DSS colitis in comparison with ulcerative colitis (UC) specimens to identify novel ...

BACKGROUND Necrotizing enterocolitis (NEC) is an inflammatory bowel disease of preterm human newborns with yet unresolved etiology. An established neonatal murine model for NEC employs oral administration of lipopolysaccharides (LPS) combined with hypoxia/hypothermia. In adult mice, feeding dextran sodium sulfate (DSS) represents a well-established model for experimental inflammatory bowel dise...

BACKGROUND The pathogenesis of dengue shock syndrome (DSS, grade 3 and 4) is not yet completely understood. Several factors are reportedly associated with DSS, a more severe form of dengue infection that reportedly causes 50 times higher mortality compared to that of dengue patients without DSS. However, the results from these reports remain inconclusive. To better understand the epidemiology, ...