BACKGROUND AND OBJECTIVES New US Down syndrome (DS) BMI growth charts were recently published, but their utility in identifying children with excess adiposity or increased cardiometabolic risk (CMR) remains unknown. We sought to compare the ability of the Centers for Disease Control and Prevention (CDC) BMI 85th percentile and DS-specific BMI 85th percentile to identify excess adiposity in chil...

We previously reported that inappropriate renal vasoconstriction in Dahl salt-sensitive (DS) rats fed high NaCl diets may cause sodium retention. The present study examined the distribution and elimination of 22Na in DS and Dahl salt-resistant (DR) rats, and we determined whether an abnormality in renal function might also cause sodium retention in DS rats. Following an intravenous bolus of 4 m...

Down's syndrome (DS) is the most common chromosomal abnormality in human. Subjects with DS are known to be peridisposed to develop leukemia. The molecular basis of the association between DS and leukemia is unknown. The unscheduled DNA synthesis (UDS) test measure the ability of DNA-repair in mammalian cells after excision of a stretch of DNA containing the region of damage induced by chemical ...

Although recent clinical trials have found an increased incidence of cardiovascular disease in women on estrogen replacement therapy, the underlying mechanism remains unclear. We have recently characterized DahlS.Z-Lepr/Lepr (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of metabolic syndrome. We have now examined the effects of estrogen...

Although recent clinical trials have found an increased incidence of cardiovascular disease in women on estrogen replacement therapy, the underlying mechanism remains unclear. We have recently characterized DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of metabolic syndrome. We have now examined the effects of ...

Down syndrome (DS) caused by trisomy of chromosome 21 is the most common genetic cause of intellectual disability. Although the prenatal diagnosis of DS has become feasible, there are no therapies available for the rescue of DS-related neurocognitive impairment. A growth inducer newly identified in our screen of neural stem cells (NSCs) has potent inhibitory activity against dual-specificity ty...

Evolutionary pressures on proteins are often quantified by the ratio of substitution rates at non-synonymous and synonymous sites. The dN/dS ratio was originally developed for application to distantly diverged sequences, the differences among which represent substitutions that have fixed along independent lineages. Nevertheless, the dN/dS measure is often applied to sequences sampled from a sin...

Down syndrome (DS) is a common genetic condition caused by the presence of three copies of chromosome 21 (trisomy 21). This greatly increases the risk of Alzheimer disease (AD), but although virtually all people with DS have AD neuropathology by 40 years of age, not all develop dementia. To dissect the genetic contribution of trisomy 21 to DS phenotypes including those relevant to AD, a range o...

Diopside (DS) is a monoclinic pyroxene mineral with composition MgCaSi2O6. Lately,diopside (DS) has beenintroduced as a bioceramics due to its best bioactivity and biocompatibility. It has a good strength andtoughness than those of hydroxyapatite (HT). In this project, bioactivity of diopside (DS) powder wereevaluated and investigated. For synthesized of diopside (DS) powder, ...

For any compact Riemannian surface of genus three $(\Sigma, ds^2)$ Yang and Yau proved that the product first eigenvalue Laplacian $\lambda_1(ds^2)$ area $Area(ds^2)$ is bounded above by $24\pi$. In this paper we improve result show $\lambda_1(ds^2) Area(ds^2) \leq 16(4 - \sqrt{7})\hspace{.02cm}\pi \approx 21.668\hspace{.02cm}\pi$. About sharpness bound, for hyperbolic Klein quartic numerical c...