Over the past decades, a number of drugs have been withdrawn or have required special labeling due to adverse effects observed post-marketing. Species differences in drug toxicity in preclinical safety tests and the lack of sensitive biomarkers and nonrepresentative patient population in clinical trials are probable reasons for the failures in predicting human drug toxicity. It is proposed that...

Idelalisib is a novel treatment option for patients with chronic lymphocytic leukemia. A rare, but, fatal complication of using Idelalsib drug induced pneumonitis. This article presents case pneumonitis in patient leukemia along brief discussion management plan.

Introduction: Janus kinase inhibitors (JAKinibs) constitute an emerging and promising pharmacological class of anti-inflammatory or anti-cancer drugs, used notably for the treatment rheumatoid arthritis some myeloproliferative neoplasms.Areas covered: This review provides overview interactions between marketed JAKinibs major uptake efflux drug transporters. Consequences regarding pharmacokineti...

Colchicine is a secondary metabolite, originally extracted from plants of the genius colchicum it consists of the dried ripe seeds of Colchicum autumnale Linn., colchicine effectively functions as a mitotic poison or spindle inhibitor but the major disadvantage of the colchicine is toxicity and non target cell (normal cell)effect. That toxicity and targeted drug delivery can be controlled by ca...

Chinese hamster ovary cells were exposed to the sulfhydryl compound cysteamine at concentrations ranging from 0 to 8 mM for 120 min. No toxicity was found in cells maintained at 5 degrees during treatment; however, at 37 degrees and 44 degrees a paradoxical toxicity was observed, i.e., substantial toxicity was observed at cysteamine concentrations of 0.2 to 1 mM but decreased at higher drug con...