This thesis developed a wearable motion capture system to record Parkinson's patients performing daily activities during each of the three stages of their medication cycle. Five calibrated accelerometers continuously monitored motions of the subjects' torso, wrists and ankles, and stored the resulting data onto a low-cost compact flash (CF) memory card. Five hours of data was recorded from a vo...

Drug testing, either on animals or 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one the key organs that filters and detoxifies blood, is susceptible drug-induced injuries. Integrating 3D bioprinting with microfluidic chips fabricate organ-on-chip platforms for liver cultures continuous perfusion can offer a more physiologically releva...

Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that is widely used for the treatment of mild-to-moderate pain. Mefenamic acid belongs to the Biopharmaceutical Classification System (BCS) class II drug which has lower water solubility but high permeability. There are two different compendial methods available for dissolution tests of mefenamic acid solid dosage forms, i.e. meth...

The purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. Propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier ...