Stevens-Johnson syndrome is an acute, inflammatory eruption of the skin and mucous membranes often associated with drug ingestion. A forty-five-year-old woman showed symptoms consistent with Stevens-Johnson syndrome two days after indapamide therapy was begun for the treatment of hypertension. Initial manifestations consisted of headaches, sore throat, cough, and symptoms of conjunctival inject...

The totality of effects of a particular drug on patients cannot be truly assessed until many patients have taken it. In order to assess the side effects of any drug, many thousands of patients may have to be observed, and the observation may have to extend over decades. Quinacrine hydrochloride (quinacrine) was used as a malarial-suppressive drug by allied soldiers during World War II. The most...

Fixed drug eruptions due to ibuprofen have rarely been reported. Two days after treatment with ibuprofen, a 61-year-old woman developed erythema and pain affecting the tongue and oral mucosa. Two months later, the patient started ibuprofen and erythromycin for a catarrhal episode with reappearance of the same lesions in the oral mucosa 24 hours later. Furthermore, two new erythematosus-violaceo...

Adverse drug reactions are a common clinical problem. It has been estimated that 6% to 15% of hospitalized patients experience some sort of adverse drug reaction. Clinical manifestations of adverse drug reactions include skin rash; a serum sickness-like reaction; drug fever; pulmonary, hepatic, and renal involvement; and systemic anaphylaxis. Many of these adverse events are not immunologically...

Selectively delivering anticancer drugs to solid tumors while avoiding their accumulation in healthy tissues is a major goal polymeric micelle research. We have recently discovered that the extravasation and permeation of micelles occur dynamic manner characterized by vascular bursts followed brief vigorous outward flow fluid (called “nano-eruptions”). Nano-eruptions allow delivery micelle-asso...

VisualDx is a clinical decision support tool that uses images and searchable clinical features to assist physicians in the diagnostic decision-making process. VisualDx is a database of more than 24,000 high-quality images covering a wide variety of conditions and drug eruptions. In addition, VisualDx integrates within both UpToDate and many electronic medical records and features a mobile versi...

articles which struck us as particularly good? that on bacteriology of the skin by Dr. Whitlield, ?" cheloid by Dr. Abraham, and on skin necrosis affections by Dr. J. Galloway. The parasitic skin diseases are ably and fully treated by Sir Malcolm Morris, and Mr. Jonathan Hutchinson Writes on drug eruptions. Dr. Whitfield's article ?n Eczema ably deals with a difficult subject. Other good articl...

On Ioto Island (Iwo-jima), 44 phreatic eruptions have been recorded since 1889, when people began to settle there. Four of these eruptions, after the beginning of continuous observation by seismometers in 1976, were accompanied by intense seismic activity and rapid crustal deformation beforehand. Other eruptions on Ioto were without obvious crustal activities. In this paper, we discuss the mech...

The principles behind the primary localization of lesions in fixed drug eruption are still unknown. Studies investigating the predilection areas indicated drug-related, trauma-related or inflammation-related specific site involvement in fixed drug eruption. This study presents new findings of primary site involvement on the maximal points of Head's zones. In the 3 cases reported here, fixed dru...