The aim of present study was to prepare and characterize the recrystallized agglomerates of water insoluble non steroidal anti-inflammatory drug, indomethacin (IM) with hydrophilic polymers like polyvinyl pyrrolidone (PVP),hydroxyl ethyl cellulose (HEC) and hydroxyl propyl methyl cellulose (HPMC) by using emulsion solvent diffusion (ESD) technique for enhancing the solubility, dissolution rate,...

In the present study solid dispersions of the antifungal drug Ketoconazole were prepared with Pluronic F-127 and PVP K-30 with an intention to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, Differential scanning calorimetery (DSC), X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obta...

Purpose: To enhance the solubility and dissolution characteristics of ketoprofen using various crystallization techniques. Methods: Ketoprofen crystals were prepared by various crystallization technique including spherical agglomeration (SA), spray drying (SD), freeze drying (FD) and super cooling (SC). The crystallization medium used for all the techniques consisted of water and chloroform. Re...

INTRODUCTION The main objective of this study was preparation and characterization of solid dispersion of piroxicam to enhance its dissolution rate. METHODS Solid dispersion formulations with different carriers including crospovidone, microcrystalline cellulose, Elaeagnus angustifolia fruit powder, with different drug to carrier ratios were prepared employing cogrinding method. Dissolution st...

The aim of the present study was to design a new biorelevant dissolution test apparatus for evaluating floating drug delivery systems. The gastric fluid secretion rate, volume of gastric fluid present in the stomach, and gastric emptying from the pylorus opening were taken into consideration. The material of construction was borosilicate glass. In vitro dissolution testing of pharmaceutical dos...

European Journal of Pharmaceutical Sciences 13 2001 123133 www.elsevier.nllocateejps. Modeling and comparison of dissolution profiles.To compare dissolution profiles between two drug products model dependent curve fitting, statistic analysis and model independent methods can be used. To compare dissolution profiles between two drug products model dependent curve fitting, statistic analysis and ...

The aim of this study was to prepare and characterize solid dispersions of water insoluble non-steroidal anti-inflammatory drug, indomethacin (IND), with polyethylene glycol 4000 (PEG4000) and Gelucire 50/13 (Gelu.) for enhancing the dissolution rate of the drug. The solid dispersions (SDs) were prepared by hot melting method at 1:1, 1:2 and 1:4 drug to polymer ratios. Scanning electron microsc...

The potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was the purpose of this survey. In this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of several amounts of them on the dissolution behaviour of indomethacin was investigated. It is worth mentio...

PURPOSE To evaluate the influence of co-administered vehicles on in vitro dissolution in simulated gastric fluid of crushed immediate release tablets as an indicator for potential drug bioavailability compromise. METHODS Release and dissolution of crushed amlodipine, atenolol, carbamazepine and warfarin tablets were tested with six foods and drinks that are frequently used in the clinical set...

PURPOSE Drug release profiles were established for ibuprofen encapsulated within several types of microspheres and a range of dissolution buffer media to study the effect these variables have in controlling the rate and extent of drug release. METHODS Fatty acid microspheres containing ibuprofen were prepared by a process previously developed and refined to produce microspheres of a known siz...