نتایج جستجو برای: drosha

تعداد نتایج: 598  

2014
Sofia Khan Dario Greco Kyriaki Michailidou Roger L. Milne Taru A. Muranen Tuomas Heikkinen Kirsimari Aaltonen Joe Dennis Manjeet K. Bolla Jianjun Liu Per Hall Astrid Irwanto Keith Humphreys Jingmei Li Kamila Czene Jenny Chang-Claude Rebecca Hein Anja Rudolph Petra Seibold Dieter Flesch-Janys Olivia Fletcher Julian Peto Isabel dos Santos Silva Nichola Johnson Lorna Gibson Zoe Aitken John L. Hopper Helen Tsimiklis Minh Bui Enes Makalic Daniel F. Schmidt Melissa C. Southey Carmel Apicella Jennifer Stone Quinten Waisfisz Hanne Meijers-Heijboer Muriel A. Adank Rob B. van der Luijt Alfons Meindl Rita K. Schmutzler Bertram Müller-Myhsok Peter Lichtner Clare Turnbull Nazneen Rahman Stephen J. Chanock David J. Hunter Angela Cox Simon S. Cross Malcolm W. R. Reed Marjanka K. Schmidt Annegien Broeks Laura J. V. a. n't. Veer Frans B. Hogervorst Peter A. Fasching Michael G. Schrauder Arif B. Ekici Matthias W. Beckmann Stig E. Bojesen Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Javier Benitez Pilar M. Zamora Jose I. A. Perez Christopher A. Haiman Brian E. Henderson Fredrick Schumacher Loic Le Marchand Paul D. P. Pharoah Alison M. Dunning Mitul Shah Robert Luben Judith Brown Fergus J. Couch Xianshu Wang Celine Vachon Janet E. Olson Diether Lambrechts Matthieu Moisse Robert Paridaens Marie-Rose Christiaens Pascal Guénel Thérèse Truong Pierre Laurent-Puig Claire Mulot Frederick Marme Barbara Burwinkel Andreas Schneeweiss Christof Sohn Elinor J. Sawyer Ian Tomlinson Michael J. Kerin Nicola Miller Irene L. Andrulis Julia A. Knight Sandrine Tchatchou Anna Marie Mulligan Thilo Dörk Natalia V. Bogdanova Natalia N. Antonenkova Hoda Anton-Culver Hatef Darabi Mikael Eriksson Montserrat Garcia-Closas Jonine Figueroa Jolanta Lissowska Louise Brinton Peter Devilee Robert A. E. M. Tollenaar Caroline Seynaeve Christi J. van Asperen Vessela N. Kristensen Susan Slager Amanda E. Toland Christine B. Ambrosone Drakoulis Yannoukakos Annika Lindblom Sara Margolin Paolo Radice Paolo Peterlongo Monica Barile Paolo Mariani Maartje J. Hooning John W. M. Martens J. Margriet Collée Agnes Jager Anna Jakubowska Jan Lubinski Katarzyna Jaworska-Bieniek Katarzyna Durda Graham G. Giles Catriona McLean Hiltrud Brauch Thomas Brüning Yon-Dschun Ko Hermann Brenner Aida Karina Dieffenbach Volker Arndt Christa Stegmaier Anthony Swerdlow Alan Ashworth Nick Orr Michael Jones Jacques Simard Mark S. Goldberg France Labrèche Martine Dumont Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Mervi Grip Vesa Kataja Veli-Matti Kosma Jaana M. Hartikainen Arto Mannermaa Ute Hamann Georgia Chenevix-Trench Carl Blomqvist Kristiina Aittomäki Douglas F. Easton Heli Nevanlinna

Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or in the miRNA binding sites may affect the miRNA dependent gene expression regulation, which has been implicated in various cancers, including breast cancer, and may alter individual susceptibility to cancer. We investigated associations between miRNA related SNPs and breast cancer risk. First we evaluated...

Journal: :Cell 2012
Inha Heo Minju Ha Jaechul Lim Mi-Jeong Yoon Jong-Eun Park S. Chul Kwon Hyeshik Chang V. Narry Kim

RNase III Drosha initiates microRNA (miRNA) maturation by cleaving a primary miRNA transcript and releasing a pre-miRNA with a 2 nt 3' overhang. Dicer recognizes the 2 nt 3' overhang structure to selectively process pre-miRNAs. Here, we find that, unlike prototypic pre-miRNAs (group I), group II pre-miRNAs acquire a shorter (1 nt) 3' overhang from Drosha processing and therefore require a 3'-en...

Journal: :The EMBO journal 2013
Jonathan Chang Brandi N Davis-Dusenbery Risa Kashima Xuan Jiang Nisha Marathe Roberto Sessa Justin Louie Wei Gu Giorgio Lagna Akiko Hata

It is widely accepted that different forms of stress activate a common target, p53, yet different outcomes are triggered in a stress-specific manner. For example, activation of p53 by genotoxic agents, such as camptothecin (CPT), triggers apoptosis, while non-genotoxic activation of p53 by Nutlin-3 (Nut3) leads to cell-cycle arrest without significant apoptosis. Such stimulus-specific responses...

Journal: :Current Biology 2004
Markus Landthaler Abdullah Yalcin Thomas Tuschl

MicroRNAs (miRNAs) represent a family of small noncoding RNAs that are found in plants and animals (for recent reviews, see ). miRNAs are expressed in a developmentally and tissue-specific manner and regulate the translational efficiency and stability of partial or fully sequence-complementary mRNAs. miRNAs are excised in a stepwise process from double-stranded RNA precursors that are embedded ...

2012
Hongjun Zhou Mary Luz Arcila Zhonghan Li Eun Joo Lee Christine Henzler Jingya Liu Tariq M. Rana Kenneth S. Kosik

With a dataset of more than 600 million small RNAs deeply sequenced from mouse hippocampal and staged sets of mouse cells that underwent reprogramming to induced pluripotent stem cells, we annotated the stem-loop precursors of the known miRNAs to identify isomoRs (miRNA-offset RNAs), loops, non-preferred strands, and guide strands. Products from both strands were readily detectable for most miR...

Journal: :RNA 2012
Yiqi Seow Christopher R Sibley Matthew J A Wood

Mirtrons are introns that form pre-miRNA hairpins after splicing to produce RNA interference (RNAi) effectors distinct from Drosha-dependent intronic miRNAs. Here we present a design algorithm for artificial mirtrons and demonstrate, for the first time, efficient gene knockdown of myotonic dystrophy protein kinase (DMPK) target sequences in Renilla luciferase 3' UTR and subsequently pathogenic ...

2015
Xingming Jiang Ning Ma Dayong Wang Fuyuan Li Rongzhang He Dongliang Li Ruiqi Zhao Qingxin Zhou Yimin Wang Fumin Zhang Ming Wan Pengcheng Kang Xu Gao Yunfu Cui

The antidiabetic drug metformin exerts antineoplastic effects in many types of malignancies, however the effect of metformin on cholangiocarcinoma (CCA) still remains unclear. In the present study, we investigated that metformin treatment was closely associated with the clinicopathologic characteristics and improved postoperative survival of CCA patients. Metformin inhibited CCA tumor growth by...

Journal: :Journal of experimental & clinical cancer research : CR 2016
Aymone Gurtner Emmanuela Falcone Francesca Garibaldi Giulia Piaggio

A widespread decrease of mature microRNAs is often observed in human malignancies giving them potential to act as tumor suppressors. Thus, microRNAs may be potential targets for cancer therapy. The global miRNA deregulation is often the result of defects in the miRNA biogenesis pathway, such as genomic mutation or aberrant expression/localization of enzymes and cofactors responsible of miRNA ma...

2012
Hironori Kawahara Takao Imai Hideyuki Okano

MicroRNA (miRNA) is a type of short-length (~22 nt) non-coding RNA. Most miRNAs are transcribed by RNA polymerase II and processed by Drosha-DGCR8 and Dicer complexes in the cropping and dicing steps, respectively. miRNAs are exported by exportin-5 from the nucleus to the cytoplasm after cropping. Trimmed mature miRNA is loaded and targets mRNA at the 3' or 5' untranslated region (UTR) by recog...

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