Retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) belong to the RIG-I-like receptors family of pattern recognition receptors. Both RIG-I and MDA5 have been shown to recognize various viral RNAs, but whether they mediate hepatitis B virus (HBV) infection remains unclear. In this study, we demonstrated that the expression of MDA5, but not RIG-I, was incr...

K e y w o r d s F o u r t h g r a d e fluid, Unsteady flow, Lie symmetries. 1. I N T R O D U C T I O N In recent years, considerable efforts have been usefully devoted to the s tudy of flow of nonNewton ian fluids. This is ma in ly due to their m a n y appl icat ions in pe t ro leum drilling, manufactu r ing of food and paper, and other similar activities. A vast a m o u n t of l i te ra ture i...

This paper examines the diverse nature of user reactions to information technology (IT) within the social-historical context of its organizational use. Employing activity theory as a conceptual framework, we conduct an interpretive analysis of physicians work, perceptions, and IT usage experience at a large community hospital to understand why some of these physicians were favorably disposed to...

Abstract We provide a rigorous workflow to quantify the effects of key sources uncertainty associated with equivalent fracture aperture estimates w constrained through mud loss information acquired while drilling well in reservoir. A stochastic inverse modeling framework is employed estimate probability distribution . This choice consistent quantity and quality available data. The approach allo...

Purpose is to determine a function of the reduced expenditures connected with drilling-and-blasting operations, loading and hauling rock fragmentation depending upon cost machine-shift applied facility, its operation modes, hardness being blasted, used explosive, quality based developed optimization mathematical model. Methods. Method statistical evaluation natural blockiness structure as well ...

The activation of retinoic acid-inducible gene I (RIG-I), an indispensable viral RNA sensor in mammals, is subtly regulated by ubiquitination. Although multiple ubiquitination sites at the amino terminus of RIG-I have been identified, their functional allocations in RIG-I activation remain elusive. We identified a stratified model for RIG-I amino-terminal ubiquitination, in which initiation at ...

Retinoic acid-inducible gene I (RIG-I) recognizes specific molecular patterns of viral RNAs for inducing type I interferon. The C-terminal domain (CTD) of RIG-I binds to double-stranded RNA (dsRNA) with the 5'-triphosphate (5'-PPP), which induces a conformational change in RIG-I to an active form. It has been suggested that RIG-I detects infection of influenza A virus by recognizing the 5'-trip...

RIG-I is a key cytosolic RNA sensor that mediates innate immune defense against RNA virus. Aberrant RIG-I activity leads to severe pathological states such as autosomal dominant multi-system disorder, inflammatory myophathies and dermatomyositis. Therefore, identification of regulators that ensure efficient defense without harmful immune-pathology is particularly critical to deal with RIG-I-ass...

BACKGROUND Retinoic acid-inducible gene-I (Rig-I) is an intracellular viral RNA receptor, which specifically recognizes double-stranded viral RNA initiating antiviral innate immunity. Increasing evidences showed that Rig-I had broader roles in antibacterial immunity and cancer protection. However, the potential roles and mechanisms of Rig-I in gut flora regulation and colorectal cancer (CRC) pr...

Retinoic acid inducible gene-I (RIG-I) is a cytosolic pathogen recognition receptor that initiates the immune response against many RNA viruses. Upon RNA ligand binding, RIG-I undergoes a conformational change facilitating its homo-oligomerization and activation that results in its translocation from the cytosol to intracellular membranes to bind its signaling adaptor protein, mitochondrial ant...