نتایج جستجو برای: dried kit

تعداد نتایج: 54448  

Journal: :Blood 2002
Jesus Pérez-Losada Manuel Sánchez-Martín Arancha Rodríguez-García Maria Luz Sánchez Alberto Orfao Teresa Flores Isidro Sánchez-García

The stem cell factor c-kit signaling pathway (SCF/c-kit) has been previously implicated in normal hematopoiesis, melanogenesis, and gametogenesis through the formation and migration of c-kit(+) cells. These biologic functions are also determinants in epithelial-mesenchymal transitions during embryonic development governed by the Snail family of transcription factors. Here we show that the activ...

2012
Sébastien Ferré Sebastian Rudolph

With the persistent deployment of ontological specifications in practice and the increasing size of the deployed ontologies, methodologies for ontology engineering are becoming more and more important. In particular, the specification of negative constraints is often neglected by the human expert, whereas they are crucial for increasing an ontology’s deductive potential. We propose a novel, arg...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شهرکرد - دانشکده دامپزشکی 1393

واریکوسل اتساع غیرطبیعی شبکه سیاهرگی بیضه ها در طناب اسپرماتیک و یکی از علت های معمول در مردان مراجعه کننده به مراکز جهت ارزیابی ناباروری است. هدف این مطالعه، ایجاد یک روش ساده و نوین جهت القای واریکوسل در سگ، ارزیابی تغییرات هیستوپاتولوژی بیضه ها ناشی از آن و بررسی میزان نسبی بیان ژن های scf و c-kit بوده است. شش قلاده سگ جوان و بالغ مورد استفاده قرار گرفت. اتساع سیاهرگ های شبکه نیلوفری از طریق...

Journal: :Cancer research 2006
Sebastian Bauer Lynn K Yu George D Demetri Jonathan A Fletcher

Inhibition of KIT oncoproteins by imatinib induces clinical responses in most gastrointestinal stromal tumor (GIST) patients. However, many patients develop imatinib resistance due to secondary KIT mutations. Heat shock protein 90 (HSP90) protects KIT oncoproteins from proteasome-mediated degradation, and we therefore did preclinical validations of the HSP90 inhibitor, 17-allylamino-18-demethox...

Journal: :Blood 1993
N Katayama J P Shih S Nishikawa T Kina S C Clark M Ogawa

We have analyzed c-kit expression by hematopoietic progenitors from normal and 5-fluorouracil (5-FU)-treated mice by staining with monoclonal anti-c-kit antibody ACK-4. Marrow cells that were enriched for progenitors by a combination of metrizamide density separation and negative immunomagnetic selection with lineage-specific monoclonal antibodies (MoAbs) were separated into three populations b...

Journal: :Cancer research 2001
B P Rubin S Singer C Tsao A Duensing M L Lux R Ruiz M K Hibbard C J Chen S Xiao D A Tuveson G D Demetri C D Fletcher J A Fletcher

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, and they are generally resistant to chemotherapy and radiation therapy. Most GISTs express the KIT receptor tyrosine kinase protein, and a subset of GISTs contain activating mutations within the KIT juxtamembrane region. We evaluated 48 GISTs, including 10 benign, 10 borderline, and 28 ...

Journal: :Journal of cell science 2014
Julhash U Kazi Shruti Agarwal Jianmin Sun Enrico Bracco Lars Rönnstrand

The Src-like-adaptor protein (SLAP) is an adaptor protein sharing considerable structural homology with Src. SLAP is expressed in a variety of cells and regulates receptor tyrosine kinase signaling by direct association. In this report, we show that SLAP associates with both wild-type and oncogenic c-Kit (c-Kit-D816V). The association involves the SLAP SH2 domain and receptor phosphotyrosine re...

Journal: :Molecular cancer therapeutics 2014
Alison C Macleod Lillian R Klug Janice Patterson Diana J Griffith Carol Beadling Ajia Town Michael C Heinrich

Resistant KIT mutations have hindered the development of KIT kinase inhibitors for treatment of patients with systemic mastocytosis. The goal of this research was to characterize the synergistic effects of a novel combination therapy involving inhibition of KIT and calcineurin phosphatase, a nuclear factor of activated T cells (NFAT) regulator, using a panel of KIT-mutant mast cell lines. The e...

2016
Ningfei An Bo Cen Houjian Cai Jin H Song Andrew Kraft Yubin Kang

BACKGROUND Receptor tyrosine kinase, c-Kit (CD117) plays a pivotal role in the maintenance and expansion of hematopoietic stem/progenitor cells (HSPCs). Additionally, over-expression and/or mutational activation of c-Kit have been implicated in numerous malignant diseases including acute myeloid leukemia. However, the translational regulation of c-Kit expression remains largely unknown. METHO...

2011
Inês Almeida Raquel Guiné Elisa Costa

The drying of pears allows their conservation due principally to the inhibition of microbial growth, making the dried pear a safe food for consumers. The knowledge of microbial flora, as well as some biochemical factors, is very important for ensuring the consumers health. In this study samples of pears of the variety S. Bartolomeu were dried under different systems: traditional open air sun dr...

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