Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome reflects a serious hypersensitivity reaction to drugs, characterized by skin rash, fever, lymph node enlargement, and internal organ involvement. So far, numerous drugs such as sulfonamides, phenobarbital, sulfasalazine, carbamazepine, and phenytoin have been reported to cause the DRESS syndrome. We report a case in a 29-yr-old ...

'The dress' is a peculiar photograph: by themselves the dress' pixels are brown and blue, colors associated with natural illuminants, but popular accounts (#TheDress) suggest the dress appears either white/gold or blue/black. Could the purported categorical perception arise because the original social-media question was an alternative-forced-choice? In a free-response survey (N = 1401), we foun...

T-cell receptor (TCR)-mediated cross-recognition is a major mechanism in the pathogenesis of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. However, the characteristics of the TCR repertoire and the clinical significance of repertoire reformation throughout the course of DRESS are unknown. Here, we isolated CD4(+) and CD8(+) T-cells from peripheral blood of 8 DRESS pati...

Drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) involves a unique and severe adverse drug reaction. Patients present with fever, rash, lymphadenopathy, hematological abnormalities, systemic illness, and may suffer from prolonged courses. Although the precise pathogenesis of DRESS/DIHS is not fully understood, it is widely considered...

DRESS syndrome is an idiosyncratic reaction to drugs, which can occur in both adults and children. To date there is no agreed upon criteria for its diagnosis; there is even less consensus on its management. We report the case of a 14- year-old boy with carbamazepine induced DRESS syndrome, predominantly involving the liver. He responded rapidly to high dose pulsed intravenous corticosteroids.

We report two cases of a 52 and 32-year-old males treated with cefotaxime. On day 23 and 28 of the treatment, the patients have manifested a clinical picture of fever, pruriginous skin rash and facial edema. Blood tests showed marked eosinophilia and atypical lymphocytosis for both patients and only hepatic cytolysis in the second patient. Cefotaxime was discontinued and the clinico-biological ...

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is diagnosed by three criteria including cutaneous drug eruption, hematologic abnormalities, and systemic involvements. The hematologic abnormalities include presence of atypical lymphocytes or eosinophilia. The systemic involvements include lymphadenopathy, hepatitis, interstitial nephritis, interstitial pneumonia, or carditis....

Prolonged Evolution of Drug ReactionWith Eosinophilia and Systemic Symptoms: Clinical, Virologic, and Biological Features Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and severe drug-induced reaction characterized by systemic involvement and an unusually long latency of onset after exposure to medication. Because this syndrome is not easily identified, it remains unde...

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