INTRODUCTION Adalimumab, an anti-tumor necrosis factor antibody, is currently available in a 40 mg/0.8 mL formulation. The objective of this analysis was to evaluate injection site-related pain, safety, and tolerability of a 40 mg/0.4 mL formulation of adalimumab that had fewer excipients, a smaller volume, and a delivery presentation with a smaller gauge needle, versus the current 40 mg/0.8 mL...

BACKGROUND Local anaesthetic creams (EMLA and Ametop) are used widely to provide pain free intravenous cannulation. However, they take a minimum of 45 minutes to become effective. AIMS To evaluate a prototype device, dermal Powderject lidocaine (DPL), that delivers high velocity lignocaine particles into the skin. METHODS A total of 132 children (aged 4-12 years) were randomised to receive ...

Abstract New nuclear monitoring technology was given an impromptu workout by the 2022 Hunga Tonga volcanic eruption. Pam Rowden outlines how one natural event tested capability of CTBT.

Objective: Berberis vulgaris has antioxidant, hepato--renal protective, antibacterial, lipid lowering, anti-inflammatory and antinociceptive activities. The genus Berberis, has another member called Berberisintegerrima which has not been studied for antinociceptive activity and therefore, this study was aimed to examine the antinociceptive effect oftotal extract and alkaloid fractions of Berber...

One of the most practical routine tests for convergence of a positive series makes use of the ratio test. If this test fails, we can use Rabbe's test. When Rabbe's test fails the next sharper criteria which may sometimes be used is the Bertrand's test. If this test fails, we can use a generalization of Bertrand's test and such tests can be continued innitely. For simplicity, we call ratio test,...

Nothing does a software company’s reputation more harm than poor quality. One significant contributor to delivered quality is how thoroughly the software is tested. In this issue of Strategic Software Engineering I will describe a test process that has a strategic impact on the organization.