Along with the rapid advances of the nextgen sequencing technologies, more and more species are added to the list of organisms whose whole genomes are sequenced. However, the assembled draft genome of many organisms consists of numerous small contigs, due to the short length of the reads generated by nextgen sequencing platforms. In order to improve the assembly and bring the genome contigs tog...

Recognition of genes via exon assembly approaches leads naturally to the use of dynamic programming. We consider the general graph-theoretical formulation of the exon assembly problem and analyze in detail some specific variants: multicriterial optimization in the case of non-linear gene-scoring functions; context-dependent schemes for scoring exons and related procedures for exon filtering; an...

abstract objective: to investigate the anesthesia-postoperative awakening time (at) of hepatitis- related cirrhosis patients and their relations to grading scores, portal venous pressure (pvp), prealbumin (pa), and age, to predict postoperative at and provide a basis for adjustment of anesthetic doses during operation. methods: atotal of 71 patients with hepatic cirrhosis and hypersplenism at a...

Protein ligand interaction fingerprints are a powerful approach for the analysis and assessment of docking poses to improve docking performance in virtual screening. In this study, a novel interaction fingerprint approach (PADIF, protein per atom score contributions derived interaction fingerprint) is presented which was specifically designed for utilising the GOLD scoring functions' atom contr...

in this paper data were collected from 120 farmers in north khorassan province for the two periods (2005-2007) in order to survey the role of rain-fed lentil risk profile for designing an insurance model. to evaluate looses of each risk, risk frequency, risk impact criteria’s as well as risk matrix were used. results showed that low risk was the largest risk area. during study period, a decreas...

Molecular docking is widely used to discovery novel ligands in structure-based drug design (SBDD) [1]. Over the past 15 years, various docking programs have been developed. Generally, flexible docking programs, such as DOCK, AutoDock, FlexX, GOLD and Glide, have the ability to predict protein-ligand complex structures with reasonable accuracy and speed. These docking programs are aimed at predi...

1 Abstract Today most VLSI circuits are built in silicon using CMOS transistors. Developments in design automation and process fabrication have resulted in the progressive increase of the number of transistors per chip and decrease in the size of the transistors. But transistor designers are fast approaching fundamental physical barriers to further size reduction. Thus engineers are looking at ...