AIM In patients with isocitrate dehydrogenase (IDH) mutated anaplastic glioma determine the dosimetric benefits of delivering radiation therapy using a PET guided integrated boost IMRT technique (ib-IMRT) compared with standard IMRT (s-IMRT) in reducing dose to normal brain. METHODS Ten patients with anaplastic glioma, identified as a favourable molecular subgroup through presence of IDH muta...

In this paper, a displacement-constrained volume-minimizing topology optimization model is present for two-dimensional continuum problems. The new model is a generalization of the displacement-constrained volume-minimizing model developed by Yi and Sui [1] in which the displacement is constrained in the loading point. In the original model the displacement constraint was formulated as an equali...

background: external beam radiotherapy (ebrt) is mainstay of treatment in patients with locally advanced cervical carcinoma (lacc). three dimensional conformal radiotherapy (3dcrt) and intensity modulated radiotherapy (imrt) are mainly used in ebrt. however which one is superior is still controversial. materials and methods: forty patients of lacc treated with imrt were selected for this study....

BACKGROUND The demand of improved dose conformity of the tumor has been increased in radiation therapy with the advent of recent imaging facilities and efficient computer technologies. AIM We compared the intensity modulated radiotherapy (IMRT) plans delivered with the sliding window (SW IMRT) and step and shoot (SS IMRT) techniques. MATERIALS AND METHODS Thirteen patients were planned on 1...

PURPOSE This study investigates the feasibility and potential benefits of radiotherapy with a 1.5T MR-Linac for locally advanced non-small cell lung cancer (LA NSCLC) patients. MATERIAL AND METHODS Ten patients with LA NSCLC were retrospectively re-planned six times: three treatment plans were created according to a protocol for conventionally fractionated radiotherapy and three treatment pla...

Dose constraints based on histograms provide a convenient and widely-used method for informing and guiding radiotherapy treatment planning. Methods of derivation of such constraints are often poorly described. Two non-parametric methods for derivation of constraints are described and investigated in the context of determination of dose-specific cut-points-values of the free parameter (e.g., per...

AbstractBackground and purpose For skull base tumors, target definition is the key to safe high-dose treatments because surrounding normal tissues are very sensitive radiation. In present work we established a joint ESTRO ACROP guideline for volume of tumors. Material methods A comprehensive literature search was conducted in PubMed using various combinations followin...

Aims: It was aimed to investigate postoperative conformal radiotherapy planning that provides the best target volume and the least dose for critical organs in cancers of stomach. Methods: This study was conducted on the CT simulation images of thirty patients diagnosed with gastric cancer. Target volumes and the organs at risk were contoured. AP-PA reciprocal parallel field conventional plan an...

Intensity-modulated radiation therapy (IMRT) is able to achieve good target conformance with a limited dose to organs at risk (OARs); however, IMRT increases the irradiation volume and monitor units (MUs) required. The present study aimed to evaluate the use of an IMRT plan with fewer segments and MUs, while maintaining quality in the treatment of nasopharyngeal carcinoma. In the present study,...