A number of ways have been investigated for administration of antibacterial agents in dealing of plaque-initiated periodontal disease. These include prolonged release intrapocket devices which are inserted at diseased sites. Intrapocket drug delivery system was designed which contain Doxycycline Hyclate an antibacterial agent. The formulations were so developed with an aim to reduce the dose of...

A number of ways have been investigated for administration of antibacterial agents in dealing of plaque-initiated periodontal disease. These include prolonged release intrapocket devices which are inserted at diseased sites. Intrapocket drug delivery system was designed which contain Doxycycline Hyclate an antibacterial agent. The formulations were so developed with an aim to reduce the dose of...

objective: to compare efficacy, safety and tolerance of combination of mifepristone and misoprostol versus misoprostol-only in induction of late intrauterine fetal death (iufd). materials and methods: this prospective study included a consecutive series of 52 women gravid up to fourth with iufd after 28 weeks of gestation between january 2008 and june 2011. women were divided into two groups. f...

The supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of surfactant and a water-soluble polymer (precipitation inhibitor or supersaturated promoter) to prevent precipitation of the drug by generating and maintaining a supersaturated state in-vivo. The supersatur...

For most patients with type 1 diabetes, the worst part of the disease is to tolerate needle after needle, both for glucose measurement and to deliver insulin. In the last two decades, concept of insulin therapy by multiple-dose injection has undergone a miraculous change. Needle-free insulin delivery appeared to be a wonderful approach, and its allure rested in being comfortable and safe. In to...

background: recent pre-clinical and clinical studies indicate that irradiation in the dose range of 15 to 30 gy can reduce rate of restenosis in patients who have undergone an angioplasty. the use of filled balloon with radioactive solution was proposed as one of the possible intravascular irradiation techniques. materials and methods: the monte carlo n-particle transport code (mcnp4b) was used...

For radiotherapy with external beams, quality assurance (QA) of beam delivery is mandatory. Dynamical irradiation which changes parameters of beam delivery devices during the irradiation has to be assessed with a great caution. At GSI a dynamic beam delivery system, so called beam tracking system [1] was developed and integrated into the GSI therapy system [2] to irradiate moving tumours with i...

BACKGROUND Optimization of factors affecting aerosol delivery during mechanical ventilation in the pediatric population is important. We hypothesized that increasing the tidal volume (V(T)), using a vibrating mesh nebulizer, and placing the nebulizer at the ventilator would increase lung dose/delivery efficiency. METHODS Continuous-output jet and vibrating mesh nebulizers loaded with albutero...

Background: The study summarised in this report aimed to investigate the interplay between fluence complexity, dose calculation algorithms, dose calculation spatial resolution and delivery characteristics (monitor units, effective field width and dose delivery against dose prediction agreement) was investigated. A sample set of complex planning cases was selected and tested using a commercial t...