Omphalocele is a known congenital anomaly consisting with a periumbilical abdominal wall defect determining the herniation of viscera into a sac made up of peritoneum, Wharton’s jelly and amnios. When the defect is larger than 5-6 cm with herniation of most of the liver and bowel into the sac, the condition is commonly referred to as giant omphalocele (GO). The latter represents a challenging s...