Objectives To analyze the patterns and risk factors of HIV drug resistance mutations among patients failing second-line treatment and to describe early treatment responses to recommended third-line antiretroviral therapy (ART) in a national referral HIV clinic in Zimbabwe. Methods Patients on boosted protease inhibitor (PI) regimens for more than 6 months with treatment failure confirmed by 2...

The kinetics of thermal decomposition of AlIII -, CrIII -, FeIII ,CeIII and LaIII -alginate complexes have been studied using thermogravimetry (TG) and differential thermogravimetry (DTG) techniques in static air. However, the TG curves showed three distinct stages of weight loss, the DTG curves indicated the presence of a series of thermal peaks associated with the TG curves. The results revea...

The aim of the present study was to evaluate the long-term effects of the caries treatment provided by a dental care program on changes in schoolchildren's OHRQoL. A one-year follow-up was conducted with a sample of 372 children aged 8 to 10 years which were clinically examined and divided into two matched groups according to their caries experience: dental treatment group (DTG) and group witho...

The thermogravimetric characteristics of wheat straw EMAL (Enzymatic Acidolysis Lignin) were analyzed. The effect of the heating rates on the thermogravimetric characteristics of wheat straw and the wheat straw influence on pyrolysis were investigated. The influence of various heating rates on wheat straw was significant, the pyrolysis rate of wheat straw EMAL increased at temperatures between ...

Background: Almost all patients treated with androgen deprivation therapy (ADT) eventually develop castration-resistant prostate cancer (CRPC). Our research aims to elucidate the potential biomarkers and molecular mechanisms that underlie transformation of primary into CRPC. Methods: We collected three microarray datasets (GSE32269, GSE74367, GSE66187) from Gene Expression Omnibus (GEO) databas...

Modern antiretroviral therapy has demonstrated effectiveness in preexposure prophylaxis (PrEP) and treatment of HIV infection. There is a demand for prevention and treatment regimens that could overcome challenges of improving adherence, toxicity, and dosing convenience. Cabotegravir is an integrase strand transfer inhibitor and an analog of dolutegravir. Unlike dolutegravir, cabotegravir has a...