نتایج جستجو برای: dna repair gene

تعداد نتایج: 1565035  

Journal: :The Journal of biological chemistry 1984
S M Cohn M W Lieberman

We have developed an immunological method for isolation and identification of DNA sequences containing 5-bromo-2'-deoxyuridine (BrdUrd) incorporated during UV-induced excision-repair synthesis. DNA fragments containing BrdUrd incorporated during repair synthesis were incubated with goat anti-BrdUrd and rabbit anti-goat IgG, and the antibody-DNA complexes were separated from bulk DNA by nitrocel...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1984
P K Gupta M A Sirover

The temporal regulation of DNA repair during synchronous cell proliferation was examined in normal human skin fibroblasts and in Bloom's syndrome skin fibroblasts. Normal human cells regulated DNA repair in a defined temporal sequence prior to the induction of DNA replication. Nucleotide-excision repair was stimulated prior to the induction of base-excision repair, which itself was increased pr...

Journal: :The EMBO journal 1997
R E Wellinger F Thoma

Nucleotide excision repair (NER) is a major pathway to remove pyrimidine dimers (PDs), a class of DNA lesions generated by ultraviolet light. Since folding of DNA into nucleosomes restricts its accessibility and since transcription and DNA repair require access to DNA, nucleosome structure and positioning as well as the transcriptional state may affect DNA repair. We recently determined the chr...

Journal: :jundishapur journal of microbiology 0
hsiu-lin huang department of biotechnology, ming dao university, chang hua, taiwan ho-ting su agriculture and food agency, council of agriculture, taipei, taiwan chung-hsiun herbert wu protein engineering and biologics development i, institute of biologics, new taipei, taiwan jyy-jih tsai-wu department of medical research, national taiwan university hospital, taipei, taiwan; department of medical research, national taiwan university hospital, 7 chung shan s. rd., taipei, taiwan. tel: +886-223123456; ext. 65759, fax: +886-223947927

background mycobacterium tuberculosis is a vicious microbe co-existing with the infected host. this pathogen exploited opportunities to spread during periods of urbanization and social upheaval, and got retreated with improved hygiene. objectives this investigation was designed to clone and characterize m. tuberculosis mutt gene, a homologue of a dna repair protein in escherichia coli. the aim ...

2009
Ana Bozas Kelly J. Beumer Jonathan K. Trautman Alenka Čopič Mariana Dorrington Silvere Pagant Justine Barry Marcus C. S. Lee Indira Singh John L. Hartman Elizabeth A. Miller Trudy F. C. Mackay Mary G. Goll Ryan Anderson Didier Y. R. Stainier Allan C. Spradling

Zinc-finger nucleases can be designed to cleave arbitrary genomic sequences, which stimulates localized mutagenesis and targeted gene replacement. Both outcomes depend on normal cellular processes of DNA repair, and this study examines the pathways responsible. Gene replacement by homologous recombination depends on the activity of the Rad51 protein. Much of local mutagenesis depends on DNA lig...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2010
Rosalyn Jewell Caroline Conway Angana Mitra Juliette Randerson-Moor Samira Lobo Jérémie Nsengimana Mark Harland Maria Marples Sara Edward Martin Cook Barry Powell Andy Boon Floor de Kort Katharine A Parker Ian A Cree Jennifer H Barrett Margaret A Knowles D Timothy Bishop Julia Newton-Bishop

PURPOSE To use gene expression profiling of formalin-fixed primary melanoma samples to detect expression patterns that are predictive of relapse and response to chemotherapy. EXPERIMENTAL DESIGN Gene expression profiles were identified in samples from two studies (472 tumors). Gene expression data for 502 cancer-related genes from these studies were combined for analysis. RESULTS Increased ...

Journal: :Investigative ophthalmology & visual science 2012
Nora Overlack Tobias Goldmann Uwe Wolfrum Kerstin Nagel-Wolfrum

PURPOSE Human Usher syndrome (USH) is the most frequent cause of inherited deaf-blindness. It is clinically and genetically heterogeneous, assigned to three clinical types of which the most severe type is USH1. No effective treatment for the ophthalmic component of USH exists. Gene augmentation is an attractive strategy for hereditary retinal diseases. However, several USH genes, like USH1C, ar...

D. Shi, H.Y. Li, J. Che, W. Zou, Y. Wang, Y.J. Zhang, Y.Y. Cui,

Background: Radiotherapy is an effective and important therapeutic method for breast cancer, but at the same time it has a radiation-induced bystander effect on normal tissue around the tumor. Repair of double-strand breaks (DSBs) by normal cells can reduce the extent of damage caused by this effect. Caveolin-1 (Cav-1) is an important regulatory molecule in cell signal transduction. However, th...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Jordi Surrallés María J Ramírez Ricard Marcos Adayapalam T Natarajan Leon H F Mullenders

A specialized nucleotide excision repair pathway known as transcription-coupled repair (TCR) counteracts the toxic effects of DNA damage in transcriptionally active genes. The clustering of active genes into gene-rich chromosomal domains predicts that the sites of TCR are unevenly distributed through the genome. To elucidate the genomic organization and chromosomal localization of TCR, we isola...

Journal: :Neuroscience 2018
Laura J Leighton Qiongyi Zhao Xiang Li Chuanyang Dai Paul R Marshall Sha Liu Yi Wang Esmi L Zajaczkowski Nitin Khandelwal Arvind Kumar Timothy W Bredy Wei Wei

Epigenetic regulation of activity-induced gene expression involves multiple levels of molecular interaction, including histone and DNA modifications, as well as mechanisms of DNA repair. Here we demonstrate that the genome-wide deposition of inhibitor of growth family member 1 (ING1), which is a central epigenetic regulatory protein, is dynamically regulated in response to activity in primary c...

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