dna profiling

Erdogan Taskesen Marije Havermans Kirsten van Lom Mathijs A Sanders Yvette van Norden Eric Bindels Remco Hoogenboezem Marcel J T Reinders Maria E Figueroa Peter J M Valk Bob Löwenberg Ari Melnick Ruud Delwel

Mutations in splice factor (SF) genes occur more frequently in myelodysplastic syndromes (MDS) than in acute myeloid leukemias (AML). We sequenced complementary DNA from bone marrow of 47 refractory anemia with excess blasts (RAEB) patients, 29 AML cases with low marrow blast cell count, and 325 other AML patients and determined the presence of SF-hotspot mutations in SF3B1, U2AF35, and SRSF2. ...

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Microarray-based gene expression studies in ovarian cancer.

Journal: :Cancer control : journal of the Moffitt Cancer Center 2011

Hye Sook Chon Johnathan M Lancaster

BACKGROUND DNA microarray technology is a powerful genomic tool that has the potential to elucidate the relationship between clinical features of cancers and their underlying biological alterations. METHODS We performed a systemic search in PubMed and Medline databases for recently published articles. The search terms used included "genome-wide," "microarrays," "ovarian cancer," "prognosis, "...

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Gene expression profiling diagnosis through DNA molecular computation.

Journal: :Trends in biotechnology 2002

Allen P Mills

Gene expression profiling is the characterization of cells based on the level of gene activity represented by concentrations of complementary DNA reverse transcribed from messenger RNA. The spectrum of cDNA concentrations, the expression profile, is determined using a DNA microarray. Although this approach is valuable for research, a simpler scheme that would give answers on a shorter time-scal...

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