Abstract Immune cell development is a tightly controlled process that enables homeostatic level of innate and adaptive immune cells the myeloid lymphoid lineages, respectively. Imbalance in can lead to diseases due defects or over-activation. such as immunodeficiency, allergies autoimmunity. Ikaros transcription factor known be critically important for development, with recurrent mutations diff...

Approximately 250 million people worldwide are chronically infected with the hepatitis B virus (HBV) and at increased risk of developing cirrhosis hepatocellular carcinoma. The HBV genome persists as covalently closed circular DNA (cccDNA), which serves template for all mRNA transcripts. Current nucleos(t)ide analogs used to treat do not directly target cccDNA thus cannot eradicate infection. H...

Recent in vitro protein-DNA binding measurements indicate that transcription factors (TFs) are bound with wide range of affinities to different DNA sequences that lack known consensus motifs, thus challenging the classical picture of specific protein-DNA binding. Our group has previously demonstrated that repetitive DNA sequence elements characterized by certain symmetries, statistically affect...

the antidiuretic effect of arginine vasopressin (avp) is mediated by the vasopressin v2 receptor. the docking study of avp as a ligand to v2 receptor helps in identifying important amino acid residues that might be involved in avp binding for predicting the lowest free energy state of the protein complex. whereas previous researchers were not able to detect the exact site of the ligand-receptor...