نتایج جستجو برای: dmf index
تعداد نتایج: 398577 فیلتر نتایج به سال:
1,3,5,7-Tetrakis(tetrazol-5-yl)-adamantane (H4L) was probed as a building block for the synthesis of tetrazolato/halido coordination polymers with open-network structures. MCl2 (M = Cu, Cd, Zn, Mn) was reacted with H4L in DMF at 70 °C to yield [Cu4Cl4L(DMF)5]·DMF, ; [Cd4Cl4L(DMF)7]·DMF, ; [Zn3Cl2L(DMF)4]·2DMF, and [Mn2L(DMF)2(MeOH)4]·DMF·2MeOH·2H2O, . and (Fddd) are nearly isostructural and hav...
We have prepared some 3d-4f cyanide-bridged Ln(DMF)4(H2O)3Fe(CN)6•H2O complexes (Ln = Ce, Sm, Nd, and Gd; DMF = N,N-dimethylformamide) by substituting isotopes to H-substituted H2O and DMF and O-substituted H2O (and normal Hand O-H2O or H-DMF). We examined their crystal structures exhibiting negative thermal expansion and compared in view of hydrogen bonds and lanthanide contraction. Magnetic p...
The mechanism of the antitumor action of N-methylformamide (NMF), an agent currently undergoing clinical trials, and its congener, N,N-dimethylformamide (DMF), was examined in the DLD-1 Clone A human colon carcinoma cell line in vitro. The primary action of NMF and DMF on these cells is a depletion of cellular reduced glutathione levels which results in cytostasis. Evidence to support this hypo...
In a series of proof-of-concept experiments using in vitro and in vivo models of ischemic stroke, we provide evidence that dimethyl fumarate (DMF) strongly reduces neuronal cell death upon ischemic insult through pleiotropic anti-inflammatory and cytoprotective effects [1, 2]. DMF is a derivative of the fumaric acid, an intermediate product of the citric acid cycle. DMF is marketed as Tecfidera...
OBJECTIVES To assess the oral health status and salivary composition in a group of children suffering from bronchial asthma. MATERIALS AND METHODS The sample consisted of sixty asthmatic children, sixty healthy negative controls, and sixty healthy positive controls of both sexes with age ranging from 4 to 12 years old. The asthmatics were grouped according to disease severity into mild, moder...
BACKGROUND Hazardous chemicals and their metabolites may accumulate in the body following repeated airborne exposures and skin contact. AIMS To estimate the contribution of skin absorption to total body burden of N,N-dimethylformamide (DMF) across a working week in two groups with similar levels of respiratory exposure but dissimilar skin contact. METHODS Twenty five workers in a synthetic ...
Delayed-release dimethyl fumarate (DMF) is an oral therapy for relapsing multiple sclerosis with anti-inflammatory and neuroprotective properties. This 2-period crossover study was conducted to evaluate the potential for drug-drug interaction between DMF (240 mg twice daily) and a combined oral contraceptive (OC; norgestimate 250 μg, ethinyl estradiol 35 μg). Forty-six healthy women were enroll...
Bone destructive diseases are common worldwide and are caused by dysregulation of osteoclast formation and activation. During osteoclastogenesis, reactive oxygen species (ROS) play a role in the intracellular signalling triggered by receptor activator of nuclear factor-κB ligand (RANKL) stimulation. Previously, we demonstrated that induction of antioxidant enzymes by Nrf2 activation using Nrf2-...
Treatment of the transformed mouse embryo fibroblast cell line (AKR-MCA) with N,N-dimethylformamide (DMF) results in a reversion to the nontransformed AKR-2B cell line phenotype. AKR-MCA cells grown in the presence of 1% DMF showed a 2-fold increase in the sites for epidermal growth factor (EGF) binding. However, most of these sites were occupied by an endogenous ligand. The EGF receptor was un...
OBJECTIVE To evaluate the effects of oral delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on MRI lesion activity and load, atrophy, and magnetization transfer ratio (MTR) measures from the Comparator and an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis (CONFIRM) study. METHODS CONFIRM was a 2-year, placebo-controlled study of the efficacy and safety of DM...
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