BACKGROUND To conduct a cost-utility analysis of ranibizumab versus aflibercept for the treatment of patients with visual impairment due to diabetic macular edema (DME) in the Greek setting. METHODS A Markov model was adapted to compare the use of ranibizumab 0.5 mg (pro re nata-PRN and treat and extend-T&E) to aflibercept 2 mg (every 8 weeks after five initial doses) in DME. Patients transit...

Introduction. To evaluate clinical feasibility and reproducibility of cytometric bead assay (CBA) in nondiluted vitreous samples of patients with age-related macular degeneration (ARMD), diabetic macular edema (DME), and central retinal vein occlusion (CRVO). Methods. Twelve patients from a single clinics day qualified for intravitreal injections (ARMD n = 6, DME n = 3, CRVO n = 3) and underwen...

Purpose To investigate the associations between soluble CD14 (sCD14), a cytokine released by microglia and macrophages, and hyperreflective foci (HF) and various characteristics of spectral-domain optical coherence tomography (SD-OCT) in diabetic macular edema (DME). Methods Sixty-nine eyes from 51 patients with DME and 28 eyes from 28 control subjects were studied. sCD14 levels in the aqueou...

PURPOSE It is controversial whether the administration of anti-vascular endothelial growth factor drugs for diabetic macular edema (DME) affects intraocular inflammatory cytokines. In this study, we measured cytokine concentration in aqueous humor before and after intravitreal injection of ranibizumab (IVR). The aim was to determine changes in cytokine concentration and their effects on DME red...

PURPOSE To evaluate if simple- or multiple-field digital color nonmydriatic (NM) retinal images can replace 7 standard stereoscopic fundus photographs in the screening of diabetic retinopathy (DR). DESIGN Prospective, masked, comparative case series. METHODS One hundred and eight eyes of 55 diabetics were studied to determine single lesions and to grade clinical levels of DR and diabetic ma...

Daily moderate exercise (DME) and stress management are underemphasized in the care of patients with lupus nephritis (LN) due to a poor comprehensive understanding of their potential roles in controlling the inflammatory response. To investigate these effects on murine LN, disease progression was monitored with either DME or social disruption stress (SDR) induction in NZM2410/J mice, which spon...

PURPOSE Diabetic macular edema (DME) is the most common cause of moderate visual disability in persons of working age in the United States. The pathogenesis of DME is poorly understood. In this study, the effect of retinal hypoxia in the development and maintenance of DME was investigated. METHODS Five patients with chronic DME despite at least one focal laser photocoagulation treatment (nine...

BACKGROUND To address the presence and features of outer retinal tubulation (ORT) found in diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (anti-VEGF) and to differentiate between ORT and cystoid DME, which have different plans of management. METHODS This was a retrospective review of a total of 514 patients investigated with spectral domain optical coherence...

Method: We examined 81 eyes of 58 consecutive patients diagnosed as DME. The condition of the posterior wall of the posterior precortical vitreous pocket (PPVP) was classified into 4 groups based on 12-mm horizontal and vertical scans through the macula using SS-OCT. Classifications were: Group 1, no posterior vitreous detachments (PVDs); Group 2, perifoveal PVD; Group 3, macular PVD; and Group...

For the last decade, dimethyl ether (DME) has been considered a promising alternative fuel for direct fuel cells because of several advantages over methanol. In this work, PtRu catalysts with a wide range of Pt-to-Ru ratios were screened for the direct DME fuel cell (DDMEFC) performance for the first time. Overall, Pt50Ru50 performs best in the high and middle voltage ranges, whereas Pt80Ru20 p...