Angiotensin II is one of the key regulatory peptides implicated in the pathogenesis of liver disease. The mechanisms underlying the salubrious role of α-tocopherol and β-carotene on liver pathology have not been comprehensively assessed. Here, we investigated the mechanisms underlying the role of Angiotensin II on hepatic damage and if α-tocopherol and β-carotene supplementation attenuates hepa...

In humans, dehydroepiandrosterone and its sulfate ester metabolite DHEA-S are secreted predominantly from the adrenal cortex, and dehydroepiandrosterone is converted to steroid hormones, including androgens and estrogens, and neurosteroid. Dehydroepiandrosterone exerts protective effects against several pathological conditions. Although there are reports on the association between dehydroepiand...

Sesamin is a major lignan in sesame seed. We confirmed that ingestion of sesamin and α-tocopherol synergistically reduced the concentration of blood cholesterol in rats given a high-cholesterol diet. To elucidate the molecular mechanism behind this effect, we analyzed the gene-expression profiles in rat liver after co-ingestion of sesamin and α-tocopherol. Six-week-old male Sprague-Dawley rats ...

Three species of kilka (Clupeonella spp.) in the Caspian Sea have a high commercial value. In Iran it is use to produce canned, marinated packs and paste in making sausage and nugget. Kilka is a nutritious fish with high level of iron and considerable level of polyunsaturated fatty acids making it prone to auto-oxidation. The quality of kilka is the most important factor affects on its products...

Some sources of corn dried distillers grains with solubles (DDGS) contain relatively high amounts of oxidized lipids produced from PUFA peroxidation during the production process. These oxidized lipids may impair metabolic oxidation status of pigs. The objective of this study was to understand the effects of feeding corn–soybean meal diets (CON) or diets containing 30% highly oxidized DDGS with...

The effect of DL-alpha-tocopherol on the differentiation of the mouse myeloid leukemia cell line (M1) was investigated using fluorometry. The reliability of the fluorometric determination was verified by the mutual overlapping of the curves of disappearance of the radioactivity recovered as alpha-tocopherol and the loss of its fluorescence. alpha-Tocopherol solubilized into the culture medium w...

This study analyzed the chemical composition and β-carotene, tocopherol retinol content of meat (musculus longissimus lumborum, musculus gluteus maximus) from young rams fed different silage-based diets. The animals were divided into four groups depending on type silage in feed ration (hybrid ryegrass, Festulolium cv. Becva, Felopa, Paulita). concentrations examined lipophilic compounds measure...

Geuk (Momordica cochinchinensis spreng) tropical fruits, which are produced in Jeju Island, Korea, well known for containing high levels of carotenoids and α-tocopherol. In this study, geuk fruits were separated two parts (pulp; yellow-orange and seed aril; red). The extracts of geuk fruits were simultaneously analyzed for carotenoids and α-tocopherol contents using HPLC. The results showed tha...

The antioxidative activity of α-tocopherol and Trolox, a water-soluble carboxylic acid derivative of α-tocopherol, in an emulsion stabilized with the hydrophilic emulsifier, polyoxyethylene (20) sorbitan monolaurate, was evaluated by measuring the changes in linoleic acid content, peroxide value, and thiobarbituric acid value. The activity of α-tocopherol and Trolox to depress the autoxidation ...