An efficient method has been developed for synthesis of 1,4-disubstituted 1,2,3-triazoles using the silica-anchored Cu(I) aminothiophenol complex [SiO2-AT-Cu(I)] as a novel heterogeneous catalyst. The prepared catalyst is characterized by the FT-IR spectroscopy, and TGA, SEM, and ICP techniques. Terminal alkynes react with aroyl bromides and sodium azide in the presence of CuI anchor...

An efficient method has been developed for synthesis of 1,4-disubstituted 1,2,3-triazoles using the silica-anchored Cu(I) aminothiophenol complex [SiO2-AT-Cu(I)] as a novel heterogeneous catalyst. The prepared catalyst is characterized by the FT-IR spectroscopy, and TGA, SEM, and ICP techniques. Terminal alkynes react with aroyl bromides and sodium azide in the presence of CuI anchor...

H a m i s h G . G r a n t * Department o f Organic Chemistry, University o f Adelaide G . P . O . B o x 498, South Australia 5001 Z. Naturforsch. 34b , 728-733 (1979); received N o v e m b e r 27, 1978 5,6-Disubstituted Indanl -ones , Crotonic Ac id , Po lyphosphor i c Ac id , 1-Methyl Benzofurocyc lopentan-3-one, 1 3C N M R The reaction of several 1,2-disubstituted benzenes with crotonic acid ...

Type 2 diabetes is one of the major life threatening diseases worldwide these cases are progressing at an incremental rate every year and number of research works are going on to control the disease by targeting its enzymes or proteins. The medicinal properties of Vitex negundo and one of its compounds, 1, 2 disubstituted idopyranose (C23H28O12) was checked against diabetes mellitus by molecula...

Carbocylization of o-halophenyl ketones with propiolates in the presence of Ni(dppe)Br2 and Zn powder in acetonitrile at 80 degrees C afforded the corresponding 2,3-disubstituted indenols.

A formal [4 + 2] annulation occurs between 1,3-disubstituted cyclobutenols and internal alkynes in the presence of rhodium(I) catalysts to afford 1,2,3,5-tetrasubstituted benzenes. These benzannulation products are generated through dehydration of the initially formed cyclohexadienols.

Correction for 'Highly regio- and stereoselective synthesis of alkenylboronic esters by copper-catalyzed boron additions to disubstituted alkynes' by Hye Ryung Kim et al., Chem. Commun., 2011, 47, 2943-2945.

Inverse electron demand Diels-Alder reaction of functionalized 5,5'-bi-1,2,4- triazines with bicyclo[2.2.1]hepta-2,5-diene in boiling p-cymene leads to a range of 6,6'- disubstituted-2,2'-bipyridines in good yield.

A series of 1,4-disubstituted 1,2,3-triazoles have been prepared in high yields while respecting the stringent Click criteria. In these reactions, highly stable pre-formed complexes bearing diimine ligands were used.

The catalytic asymmetric phospha-Michael reaction of dialkyl phosphine oxides with β,β-disubstituted α,β-unsaturated carbonyl compounds was achieved. The products bearing tetrasubstituted carbon stereocenters were obtained in high yields with excellent enantioselectivities (up to >99% ee).