OBJECTIVE To report the percentile distribution of Mini-Mental State Examination (MMSE) scores in older people by age, sex, and education level, estimated from longitudinal data, after correcting for loss due to dropout. METHODS The Cambridge City over 75 Cohort is a population-based study of a cohort of 2106 subjects age 75 years and older at study entry followed up over 9 years. At each of ...

Purpose Glucocorticoids are widely used medications. In many pharmacoepidemiological studies, duration of individual prescriptions and definition of treatment episodes are important issues. However, many data sources lack this information. We aimed to estimate duration of individual prescriptions for oral glucocorticoids and to describe continuous treatment episodes using the parametric waiting...

Using conditional and unconditional quantile regressions this paper finds that the Mexican conditional cash transfer program PROGRESA Oportunidades has had a positive but distributionally regressive effect on the birthweight of babies born into enrolled households. The program impact varies from 135 grams on birthweights at the 20th percentile of the conditional distribution to 207 grams on bir...

BACKGROUND AND PURPOSE Our purpose was to determine the characteristic MR features of early-onset (before age 2 years) versus late-onset (after age 2 years) globoid cell leukodystrophy (GLD). METHODS Thirty-four brain MR images in 22 patients with GLD were reviewed. A severity score (0 to 32), based on a point system derived from the location and extent of disease and the presence of focal an...

Introduction Tolerancing an optical system has traditionally fallen between an art and a science. Experience and intuition has driven optical engineers for decades in deciding the appropriate tolerances to place on optical components and the mechanics holding them. In an effort to systematically quantify this process, mathematical methods have been reported by Warren Smith, Ronald Willey, and o...

BACKGROUND Peak expiratory flow ("peak flow") predicts important outcomes in older persons. Nevertheless, its clinical application is uncertain because prior strategies for reporting peak flow may not be valid. We thus determined the frequency distribution of peak flow by the conventional strategy of percent predicted (%predicted) and by an alternative method termed standardized residual (SR) p...