Endogenous endophthalmitis is a vision-threatening condition that results from hematogenous spread of infection to the eye, originating from a distant primary focus. It is considered as a rare entity that predominantly occurs in immune-compromised patients. We present a case of a critically ill immune-competent patient who underwent abdominal surgery later followed by nosocomial urosepsis compl...

Often, researchers study organizations in which design is largely in place and the design process is shrouded in the distant past. However, the design process can have dramatic implications for how organizations function. This paper reports a specific attempt to design one organizational subunit, a pediatric intensive care unit (PICU), to function under difficult circumstances. The founders aim...

We consider the problem of autonomous navigation in an unstructured outdoor environment. The goal is for a small outdoor robot to come into a new area, learn about and map its environment, and move to a given goal at modest speeds (1 m/s). This problem is especially difficult in outdoor, off-road environments, where tall grass, shadows, deadfall, and other obstacles predominate. Not surprisingl...

Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature forebrain. Genetic disruption of choroid-expressed Otx2 impacts these distant ci...

Autonomous robot guidance in dynamic environments requires, on the one hand, the study of relative motion of the objects of the environment with respect to the robot, and on the other hand, the analysis of the depth towards those objects. In this paper, a stereo vision method, which combines both topics with potential utility in robot navigation, is proposed. The goal of the stereo vision model...

The author argues that a particular kind of departmental leadership is needed lest medical education become hostage both to distant management through regulatory metrics (which can displace local, institutional creativity) and to the financial pressures within the institution. Departmental chairs themselves have often been seen as barriers to successful integration and redesign of medical schoo...

Various problems in Computer Vision become difficult due to a strong influence of lighting on the images of an object. Recent work showed analytically that the set of all images of a convex, Lambertian object can be accurately approximated by the low-dimensional linear subspace constructed using spherical harmonic functions. In this paper we present two major contributions: first, we extend pre...