Pharmaceutical sciences experts and regulators acknowledge that pharmaceutical development as well as drug usage requires more than scientific advancements to cope with current attrition rates/therapeutic failures. Drug disease modeling and simulation (DDM&S) creates a paradigm to enable an integrated and higher-level understanding of drugs, (diseased)systems, and their interactions (systems ph...

In our previous work, an effective preconditioning scheme that is based upon constructing least-squares approximation cardinal basis functions (ACBFs) from linear combinations of the RBF-PDE matrix elements has shown very attractive numerical results. The preconditioner costs O(N2) flops to set up and O(N) storage. The preconditioning technique is sufficiently general that it can be applied to ...

The most important physico-chemical characteristics describing detergent micelles are the CMC value and the aggregation number. These parameters depend critically on external conditions such as pH, ionic strength, buffer composition or temperature. However, the influence of these conditions on CMC or aggregation number is a priori not to predict, but the most important parameter. This holds esp...

The surrounding rock stability of an underground cavern group is important issue in the process excavation, which has characteristics large displacement, discontinuity and uneven deformation, so calculation analysis are very complicated. optimized discontinuous deformation for failure method was adopted to analyze a real engineering under different excavation schemes. cracking schemes, depth cr...

We report on the retrieval of directional sea surface roughness, in terms of its full directional mean square slope (including direction and isotropy), from Global Navigation Satellite System Reflections (GNSS-R) Delay-Doppler-Map (DDM) data collected during an experimental flight at 1 km altitude. This study emphasizes the utilization of the entire DDM to more precisely infer ocean roughness d...

This study presents the results from the analyses of verbal protocols elicited from inexperienced and experienced participants of a real-time, Dynamic Decision-Making (DDM) task. This research intends to complement a series of studies performed in DDM environments analyzing the cognitive structures and processes involved in learning in DDM. Results show that inexperienced and experienced partic...

Single thread performance improvement using more complex structures and higher frequencies is currently reaching its limits. As such, several architectures that target this problem through exploiting coarse grainedmultithreading have been proposed. Such an architecture is the DataDriven Multithreading Chip Multiprocessor (DDM-CMP) which is based on a dataflow-like model of execution. To fully e...

Wind speed and direction are important essential climate variables (ECVs). GNSS-R is an emerging remote sensing technique that can be potentially used to retrieve wind speed from space. However, few studies have addressed the wind direction retrieval from spaceborne GNSS-R observables, namely the Delay Doppler map (DDM). In this study, the feasibility of retrieving wind direction from the synth...