Two extracts of different collections of the traditional medicine uña de gato (Uncaria tomentosa) from Peru were characterized by High Pressure Liquid Chromatography as containing approximately 6 mg/g total oxindole content prior to studies with alveolar macrophages. The plant preparations greatly stimulated IL-1 and IL-6 production by rat macrophages in a dose dependent manner in the range of ...

A series of (E) and (Z)-ferrocenyl oxindoles were prepared by coupling substituted oxindoles to ferrocenylcarboxyaldehyde in the presence of morpholine as a catalyst. The redox behavior of these isomers was determined by cyclic voltammetry. The effects of the oxindole derivatives on the migration of human breast cancer cells were evaluated using the wound-healing assay and the Boyden chamber ce...

The FDA has called for the detention of all imports of dietary supplements and bulk dietary ingredients that are or contain Mitragyna speciosa or the natural product kratom derived from this plant, due to the toxicity of kratom in multiple organ systems. The toxicity and psychoactive properties of this plant necessitate improved analytical techniques for the separation of the indole and oxindol...

Cat’s claw oxindole alkaloids are prone to isomerization in aqueous solution. However, studies on their behavior in extraction processes are scarce. This paper addressed the issue by considering five commonly used extraction processes. Unlike dynamic maceration (DM) and ultrasound-assisted extraction, substantial isomerization was induced by static maceration, turbo-extraction and reflux extrac...

Funapide is a 3,3’-spirocyclic oxindole with promising analgesic activity. A reported pilot-plant scale synthesis of this chiral compound involves an asymmetric aldol reaction, catalyzed by common bifunctional thiourea structure. In work, we show that the swapping unit catalyst for tailored squaramide group provides equally active, but rewardingly more selective, reaction (from 70.5 to 85 % ee)...