Due to their conformational malleability, intrinsically disordered proteins (IDPs) are particularly susceptible to influences of crowded cellular environments. Here we report a computational study of the effects of macromolecular crowding on the conformational ensemble of a coarse-grained IDP model, by using two approaches. In one, the IDP is simulated along with the crowders; in the other, cro...

Intrinsically disordered proteins are highly abundant in various proteomes. They are different from ordered proteins at many levels, and their structural and functional characterization requires special experimental and computational tools.

A critical examination of speech motor control depends on an in-depth understanding of network connectivity associated with Brodmann areas 44 and 45 and surrounding cortices. Damage to these areas has been associated with two conditions-the speech motor programming disorder apraxia of speech (AOS) and the linguistic/grammatical disorder of Broca's aphasia. Here we focus on AOS, which is most co...

Introduction: There is a long-term interest in the effects of undesirable emotions to eating behaviors, due to the strain that it places on a person which can lead to loses his/her health. The present study examined the degree of disordered eating behaviors related to anxiety and alexithymia among high schools girls.Materials and Methods: This cross-sectional study on 344 girl students of Tehra...

Strong, tough, stretchable, and self-adhesive hydrogels are designed with intrinsically unstructured proteins. The extraordinary mechanical properties exhibited by these materials are enabled by an integration of toughening mechanisms that maintain high elasticity and dissipate mechanical energy within the protein networks.

Sequence specific resonance assignment is the prerequisite for the NMR-based analysis of the conformational ensembles and their underlying dynamics of intrinsically disordered proteins. However, rapid solvent exchange in intrinsically disordered proteins often complicates assignment strategies based on HN-detection. Here we present a six-dimensional alpha proton detection-based automated projec...

FAS is a speech disorder characterized by changes to the normal speech patterns of the native language. This speech impairment is usually due to stroke or brain injury. Segmental, suprasegmental and prosodic features are altered. FAS speakers’ speech is perceived as foreign rather than disordered. It may be because the speech remains highly accurate and the impairments are generally within the ...

BACKGROUND Voice disorders affect patients profoundly, and acoustic tools can potentially measure voice function objectively. Disordered sustained vowels exhibit wide-ranging phenomena, from nearly periodic to highly complex, aperiodic vibrations, and increased "breathiness". Modelling and surrogate data studies have shown significant nonlinear and non-Gaussian random properties in these sounds...

Speech is the primary means of human communication. Speech production starts in early ages and matures as children grow. People with intellectual or learning disabilities have deficit in speech production and faces difficulties in communication. These people need tailor-made therapies or trainings for rehabilitation to lead their lives independently. To provide these special trainings , it is i...

Three-bond (3)J(C'C') and (3)J(HNHα) couplings in peptides and proteins are functions of the intervening backbone torsion angle ϕ. In well-ordered regions, (3)J(HNHα) is tightly correlated with (3)J(C'C'), but the presence of large ϕ angle fluctuations differentially affects the two types of couplings. Assuming the ϕ angles follow a Gaussian distribution, the width of this distribution can be e...