BACKGROUND Measuring coronary artery calcium score (CACS) using a dual-source CT scanner is recognized as a major indicator for assessing coronary artery disease. The present study aimed to validate the clinical significance of CACS in predicting coronary artery stenosis and its severity. MATERIAL/METHODS This prospective study was conducted on 202 consecutive patients who underwent both conv...

Alopecia areata (AA) is an autoimmune disease typified by nonscarring hair loss with a variable clinical course. In this study, we conducted whole genome gene expression analysis of 96 human scalp skin biopsy specimens from AA or normal control subjects. Based on gene expression profiling, samples formed distinct clusters based on the presence or absence of disease as well as disease phenotype ...

Background: Seborrheic dermatitis (SD) is an inflammatory disease affecting seborrheic areas of the skin. Scalp SD varies from mild, manifesting as dandruff, to erythematous lesions with greasy scales. SD negatively affects patients’ quality of life.Methods: This is a cross-sectional study investigating the relationship between quality of life and disease severity in pa...

The aim of this study was to evaluate the utility of the Charcot-Marie-Tooth Neuropathy Score (CMTNS) for evaluation of disease severity in young children with Charcot-Marie-Tooth type 1A. Current validated scoring scales for Charcot-Marie-Tooth are the CMTNS and the Neuropathy Impairment Score (NIS). Both work well for adult patients, and usually also for children over 10 years of age. There i...

Severity assessment in laboratory animals is an important issue regarding the implementation of the 3R concept into biomedical research and pivotal in current EU regulations. In mouse models of inflammatory bowel disease severity assessment is usually undertaken by clinical scoring, especially by monitoring reduction of body weight. This requires daily observance and handling of each mouse, whi...

Background: The skin of patients with atopic dermatitis has a high susceptibility to staphylococcus aureus (S. aureus) colonization known to produce toxins with super antigen (SAgs) activity which are a family of potent immune-stimulatory exotoxins and may aggravate AD. The aim of this research was to evaluate the ro...

OBJECTIVE The aim of the study reported here was to validate the risk-scoring algorithm for prognostication of scrub typhus severity. METHODS The risk-scoring algorithm for prognostication of scrub typhus severity developed earlier from two general hospitals in Thailand was validated using an independent dataset of scrub typhus patients in one of the hospitals from a few years later. The pred...

Objective: Cardiovascular risk increases in patients with schizophrenia. In our study, it was aimed to predict the 10-year of developing cardiovascular disease using Framingham score schizophrenia living nursing homes
 Materials and Methods: sociodemographic clinical characteristics homes, such as age, gender, educational status, duration disease, treatments used, scoring which included ge...