In the past, cancer survivors tended to be most concerned about disease recurrence and treatment side effects. As survival rates have increased, however, patients are now also concerned about quality-of-life issues such as preserving fertility potential. It is well known that cancer treatment adversely affects male fertility via direct effects on the testis and/or through the endocrine glands. ...

Since inception, pathology has served as the indispensable link between basic science and clinical disease, encompassing the defining of disease processes and mechanisms through observation of structural alterations, as well as hypothesis-driven experimentation. The careful study of pathology has delivered an understanding of disease sufficient to guide effective treatment, and recognize ineffe...

Adamantiades-Behçet disease (ABD) is a chronic multisystemic vasculitis that is able to affect any human organ or system. Recurrent oral ulcers are a very important clinical sign. ABD is a worldwide pathology, which prevalence varies according to the population and geographic location. Although ABD has been known for ages, its aetiology remains an enigma. Genetic, immunological and microbiologi...

Neurofibrillary degeneration is well correlated to the clinical signs of Alzheimer disease. However, the amyloid cascade is so well established in the scientific and medical community that the role of neurofibrillary degeneration in Alzheimer's disease etiopathogenesis is often underestimated. However, neuronal vulnerability is clearly a key factor for facilitating the amyloid pathology which a...

Object-oriented design and layered hierarchical architecture are the dominant paradigms for building computerbased applications. The biological system has significant nonoverlap with these paradigms. This poses challenges in integrating seamlessly computer and biological systems. A seamless system could help build personalized patient monitoring/management systems for chronic conditions such as...

I n their article in this month's issue of Diabetes Care, Hummell et al. (1) tested the hypothesis that gluten is a driving antigen for type 1 diabetes–associated is-let autoimmunity. They convincingly demonstrated that elimination of dietary gluten for 12 months in humans positive for at least two type 1 diabetes–associated autoantibodies does not consistently alter the titers of these antibod...

aim : evaluation of biological characteristics of 13 identified proteins of patients with cirrhotic liver disease is the main aim of this research.   background : in clinical usage, liver biopsy remains the gold standard for diagnosis of hepatic fibrosis. evaluation and confirmation of liver fibrosis stages and severity of chronic diseases require a precise and noninvasive biomarkers. since the...

The aim of this study was to examine the contribution of controlled (or conscious) and automatic (or unconscious) memory processes to the performance of a stem-completion recall task by persons with Alzheimer's disease and a matched group of healthy elderly individuals. The recall task made use of the process dissociation procedure of Jacoby (1991), which allows the separate estimation of consc...

Comprehensive approach study aimed understanding the reflections and contrasts between personal time and medical therapy protocol time in the life of a young woman with breast cancer. Addressed as a situational study and grounded in Beth's life story about getting sick and dying of cancer at age 34, the study's data collection process employed interviews, observation and medical record analysis...