نتایج جستجو برای: directagglutination test dat
تعداد نتایج: 814853 فیلتر نتایج به سال:
Visceral leishmaniasis (VL) or kala-azar is a parasitic disease caused by Leishmania donovani complex. Evidence suggests that visceral leishmaniasis is prevalent in some areas of Mazandaran and Golestan provinces. This study aimed to investigate the cases and also determining the causative agents of VL in these provinces. In this study, seven VL patients (mean age 1.5 years) admitted to the ped...
The dopamine transporter (DAT) plays a key role in the regulation of dopaminergic signaling wherein it controls both the spatial and temporal actions of dopamine. Here we evaluated the behavioral and neurochemical consequences of increased DAT function by generating DAT transgenic mice (DAT-tg) that overexpress the transporter. These mice were generated by pronuclear injection of a bacterial ar...
The widespread abuse of cocaine, a highly addictive psychostimulant, places tremendous social, medical, and economic burdens on society. By improving our understanding of the underlying mechanisms of cocaine addiction, it may be possible to develop more effective therapeutic strategies and social policies aimed at reducing the abuse of cocaine. Cocaine inhibits the uptake of monoaminergic neuro...
Parkinsonism and attention deficit hyperactivity disorder (ADHD) are widespread brain disorders that involve disturbances of dopaminergic signaling. The sodium-coupled dopamine transporter (DAT) controls dopamine homeostasis, but its contribution to disease remains poorly understood. Here, we analyzed a cohort of patients with atypical movement disorder and identified 2 DAT coding variants, DAT...
The Caenorhabditis elegans (C. elegans) dopamine (DA) transporter (DAT-1) regulates DA signaling through efficient DA reuptake following synaptic release. In addition to its DA transport function, DAT-1 generates detectable DA-gated currents that may influence neuronal excitability. Previously, we provided evidence that single Cl-channel events underlie DAT-1 currents. In these studies, we iden...
The reinforcing effects of cocaine and methylphenidate have been linked to their ability to block dopamine transporters (DAT). Using positron emission tomography (PET), we previously showed that intravenous cocaine induced a significant level of DAT blockade, which was associated with the intensity for self-reports of "high" in cocaine abusers. In this study, we measured DAT occupancies after i...
Dysregulation of dopamine (DA) homeostasis is implicated in neurodegenerative diseases, drug addiction, and neuropsychiatric disorders. The neuronal plasma membrane dopamine transporter (DAT) is essential for the maintenance of DA homeostasis in the brain. α-Synuclein is a 140-amino acid protein that forms a stable complex with DAT and is linked to the pathogenesis of neurodegenerative disease....
BACKGROUND This study aimed to evaluate freeze-dried sera as an alternative to non-freeze dried for detection of anti-Leishmania infantum antibodies over the course of 11 months using the direct agglutination test (DAT). METHODS Altogether, 60 serum samples (30 from humans and 30 from dogs) were collected from various geographical locations in Iran. All the collected sera were pooled and each...
leishmaniasis (vl) is a life-threatening vector-borne parasitic disease is distribut-ed in some parts of the new world and old world. the disease is endemic in different parts of iran. this review article has been focused on major topics of epidemiological aspects and clinical features of vl in iran for the period of 2002 through 2012. for the detection of vl in humans as well as animal reservo...
background: surveillance of the canine reservoir is highly important to help control of visceral leishmaniasis in human. it is therefore imperative to improve and develop new tools reliable, easy to use, and cheap for the diagnosis of canine leishmani asis. k39 sub recombinant antigen of leishmania infantum was expressed in prokaryotic system and evaluated for sero-diagnosis of canine visceral ...
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