The overall objective of this study is to non-invasively image and assess tumor targeting and retention of directly labeled T-lymphocytes following their adoptive transfer in mice. T-lymphocytes obtained from draining lymph nodes of 4T1 (murine breast cancer cell) sensitized BALB/C mice were activated in-vitro with Bryostatin/Ionomycin for 18 hours, and were grown in the presence of Interleukin...

Purpose To perform lung image registration for reducing misregistration artifacts on three-dimensional (3D) temporal subtraction of chest computed tomography (CT) images, in order to enhance temporal changes in lung lesions and evaluate these changes after deformable image registration (DIR). Methods In 10 cases, mutual information (MI) lung mask affine mapping combined with cross-correlation...

In recent years one of the areas of interest in radiotherapy has been adaptive radiation therapy (ART), with the most efficient way of performing ART being the use of deformable image registration (DIR). In this paper we use the distances between points of interest (POIs) in the computed tomography (CT) and the cone beam computed tomography (CBCT) acquisition images and the inverse consistence ...

OBJECTIVE Determine the results of 1-year Developmental, Individual-Difference, Relationship-Based (DIR)/Floortime parent training in developmental stimulation of children with autistic spectrum disorder (ASD). MATERIAL AND METHOD Thirty-four, two to six years old children with ASD participated. Parents were encouraged to deliver 1:1 interaction according to their child's developmental level,...

The optimal choice of routing and wavelength assignment (RWA) for the working and protection path–pair of the newly generated demand request is often a complex problem in reliable wavelength-division-multiplexed (WDM) networks subject to dynamic traffic. The challenge is twofold: how to provide the required reliability level without over-reserving network resources and how to find a good soluti...

OBJECTIVE To analyze the maternal mortality in the ABC Region, comparing indicators from the Committee for the Study of Maternal Mortality in the Great ABC Region (CEMM) of the II Regional Health Center of Santo Andre (DIR II), and the State Data Analysis System Foundation (SEADE). METHODS This is a cross sectional study. The information was obtained from the database of CEMM DIR II - Santo A...

In a two-step strategy, an intraperitoneal (IP) injection of poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) micelles containing paclitaxel (PTX), cyclopamine (CYP), and gossypol (GSP) at 30, 30, and 30 mg/kg, respectively, debulked tumor tissues by 1.3-fold, based on loss of bioluminescence with <10% body weight change, and induced apoptosis in peritoneal tumors when used as neoad...

It has recently been shown that deep neural networks (DNN) can improve the quality of statistical parametric speech synthesis (SPSS) when using a source-filter vocoder. Our own previous work has furthermore shown that a dynamic sinusoidal model (DSM) is also highly suited to DNN-based SPSS, whereby sinusoids may either be used themselves as a “direct parameterisation” (DIR), or they may be enco...

Three competing models of cognitive aging (neural compensation, capacity limitations, neural inefficiency) were examined in relation to working memory for novel non-verbal material. To accomplish this goal young (n=25) and old (n=25) participants performed a delayed item recognition (DIR) task while being scanned with bold fMRI. The stimuli in the DIR task consisted of computer-generated closed...

We study the multiway cut problem in directed graphs and one of its special cases, the node-weighted multiway cut problem in undirected graphs. In DIRECTED MULTIWAY CUT (DIR-MC) the input is an edge-weighted directed graph G = (V,E) and a set of k terminal nodes {s1, s2, . . . , sk} ⊆ V ; the goal is to find a min-weight subset of edges whose removal ensures that there is no path from si to sj ...