نتایج جستجو برای: dinuclear zinc metallo β lactamase
تعداد نتایج: 260020 فیلتر نتایج به سال:
Two major hospitals in Kano, North West Nigeria have recorded increasing resistance of clinical pathogens to broad spectrum β lactams, mediated by extended spectrum β-lactamase (ESβL) and non ESBLs. A study was therefore undertaken to determine the occurrence and prevalence of plasmid and chromosomal mediated AmpC βL and carbapenemase in addition to already known ESBL due to increasing resistan...
Enzymes capable of hydrolyzing N-acyl- l-homoserine lactones (AHLs) used in some bacterial quorum-sensing pathways are of considerable interest for their ability to block undesirable phenotypes. Most known AHL hydrolases that catalyze ring opening (AHL lactonases) are members of the metallo-beta-lactamase enzyme superfamily and rely on a dinuclear zinc site for catalysis and stability. Here we ...
Resistance to 3rd generation cephalosporins in Salmonella has been attributed to the production of extended spectrum β-lactamases (ESBLs), but AmpC and KPC or metallo β-lactamase (MBL) mediated resistance have also been reported1. ESBLs reported in Salmonella spp. are the derivatives of TEM, SHV, CTX-M and PER type β-lactamase families1. We isolated Salmonella enterica ser. Typhimurium (B9903) ...
New Delhi metallo-β-lactamase-1 (NDM-1) is a recently identified metallo-β-lactamase that confers resistance to carbapenems and all other β-lactam antibiotics, with the exception of aztreonam. NDM-1 is also associated with resistance to many other classes of antibiotics. The enzyme was first identified in organisms isolated from a patient in Sweden who had previously received medical treatment ...
prevalence of metalo- β-lactamase-producing (mbl) acinetobacter species in a tertiary care hospital.
background and objectives: acinetobacter causes a wide variety of illness in debilitated and hospitalized patients. carbapenem resistance in acinetobacter is an emerging problem and is a cause of concern as many nosocomial infections with acinetobacter are resistant to most other antibiotics. the present study was aimed to study metallo-β-lactamase (mbl) production in acinetobacter species. mat...
Streptococcus pneumoniae, a penicillin-sensitive bacterium, is recognized as a major cause of pneumonia and is treated clinically with penicillin-based antibiotics. The rapid increase in resistance to penicillin and other antibiotics affects 450 million people globally and results in 4 million deaths every year. To unveil the mechanism of resistance of S. pneumoniae is thus an important issue t...
Zinc complexes bearing the anilido-aldiminate AA(OMe) ligand (AA(OMe)-H = (E)-2,6-diisopropyl-N-(2-(((2-methoxyethyl)imino)methyl)phenyl)aniline) were synthesized in a stepwise method and were structurally characterized. The reaction of AA(OMe)-H (1) with one equivalent of diethyl zinc (ZnEt2) furnishes a three-coordinated and mononuclear zinc complex [(AA(OMe))ZnEt] (2). Further reaction of 2 ...
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