Neurotoxicity is a clinically relevant adverse event observed with the use of ifosfamide. It is usually mild, occasionally severe and seldom fatal. Ifosfamide-induced encephalopathy requires interruption of chemotherapy, intravenous hydration and administration of methylene blue. Less is known about the efficacy of methylene blue in avoiding a second episode of ifosfamide-induced encephalopathy...

This case report by Naik et al. of probable serotonin toxicity in a patient previously taking venlafaxine, who was then given intravenous methylthionimium (aka methylene blue) during a parathyroid surgical procedure (1), is a typical example of a perennial problem in medical publishing. The case is unremarkable, except for the fact that it is of concern that methylene blue was given at all, bea...

required to reduce the methylene blue. It is clear that the long lag phase observed when methylene blue was present before all the oxygen was removed is due to an inhibition by methylene blue of the systems of the cell which consume oxygen. Summary. The rates of the exchange reaction and of the reduction of various dyes and other acceptors have been compared in a number of different microorgani...

Carbon monoxide:methylene blue oxidoreductase, the key enzyme of CO-oxidation in energy metabolism of the carboxydobacterium Pseudomonas carboxydovorans, has been isolated in good yield and purity and found to contain FAD, molybdenum, iron, and labile sulfide in the ratio of 1:1:4:4. The enzyme is, therefore, a new molybdenum-containing iron-sulfur flavoprotein, exhibiting chemical and spectral...

Background and Aim: The mismatch of the implant-abutment connection can produce instant stress and microleakage which result in mechanical and biological complications. This study aimed to investigate the influence of GapSeal® as a sealing material on the extent of microgap and microleakage at the external hexagon implant platform following cyclic loading. Materials and Methods: Sixteen implan...

Methylene blue was efficiently removed from aqueous solution by foam flotation using a rhamnolipid a biosurfactant as a dye collector. The effects of four parameters, namely, pH (1.5–11.5), frother concentration (5–65 ppm), aeration rate (2–6 L/min) and rhamnolipid to methylene blue weight ratio (0.5–6.5), on dye removal were studied and optimized using response surface methodology. Results...

In this study, removal of methylene blue by electro-coagulation method using aluminum and iron electrodes was investigated. The influence of the operating parameters such as contact time, current density, anode type, inter-electrodes distance, initial and final pH and energy consumption rate was determined. Dye removal was increased with increases in solution pH, current density and c...

Background & objectives: The release of dyestuff wastewaters produced in textile industry into receiving waters affects both human health and the environment. The aim of this study was to investigate the efficiency of a photocatalytic UV/persulfate process in removal of methylene blue and acid green 3 dyes from aqueous solutions. Methods: The current study was an experimental study, in which t...

The red blood cell hexose monophosphate shunt (HMS) and proteolytic responses to several concentrations of Methylene Blue or sodium nitrite were measured. The results suggested two distinct mechanisms for activation of the HMS: (1) nitrite treatment increased HMS activity in response to oxidative challenge to red cell protein; (2) Methylene Blue treatment activated HMS without injurious oxidati...

To report a case of methylene blue related endophthalmitis. Observational case report. Review of clinical record, photographs. A 60 year old man developed endophthalmitis after methylene blue was accidentally used to stain the anterior capsule during phacoemulsification of cataract. His left visual acuity deteriorated from 6/12 to 6/36 two weeks after the operation. Despite intensive treatment ...