BACKGROUND Tyrosine kinase inhibitors (TKIs) have been associated with elevated TSH as a drug class effect. Prior studies of vandetanib in adults with medullary thyroid carcinoma (MTC) described an increase in levothyroxine (LT) requirement. We studied TSH, free T4, and LT dosing in children and adolescents enrolled in the phase I/II trial of vandetanib for medullary thyroid cancer (MTC). MET...

BACKGROUND Rapid growth of thyroid nodules is described as being associated with thyroid cancer. The objective of the study was to determine how the growth rate of thyroid nodules during follow-up is associated with the risk of thyroid cancer. METHODS Retrospective analysis of patients undergoing thyroid surgery for nodular disease and a repetitive preoperative ultrasound work-up of at least ...

Abstract Aims Levothyroxine (LT4) therapy is necessary post total thyroidectomy to suppress TSH for differentiated thyroid cancer (DTC) and euthyroidism benign disorders. We aim evaluate the accuracy of empirical LT4 regimens alongside existing formulas in literature identify predictive variables dosage. Methods Retrospective study between January 2018 February 2021 all thyroidectomies at UHNM....

Functional thyroid carcinoma is an unusual cause of thyrotoxicosis. We describe the clinical presentation and treatment of a patient with thyrotoxicosis due to functional thyroid carcinoma and Graves disease, and discuss potential mechanisms causing the thyrotoxicosis. A 79-year-old woman with a remote history of hemithyroidectomy and current hyperthyroidism came to the hospital with upper and ...

Routine treatment of thyroid cancer (TC) includes long-term suppression of TSH. The necessity of this treatment in low- and intermediate-risk patients as well as the extent of TSH suppression is currently under discussion. A literature search was performed to illustrate the role of TSH in extrathyroidal cells and to identify potential reasons for different effects of exogenously suppressed and ...

OBJECTIVE The current study aimed to determine the efficacy of radioiodine-131 ((131)I) ablation therapy with thyroid hormone replacement one day before (131)I administration in patients with well-differentiated thyroid cancer (DTC). METHODS This retrospective study included 29 patients who underwent (131)I therapies twice for DTC during 6-12 months. Since all the patients obviously had resid...

Dear Editor, About : “Çalık A, Küçüktülü U, Bilgin Y, Çinel A, Alhan E, Pişkin B. Prevention of recurrences after thyroidectomy in an endemic area with prophylactic levothyroxine use. Tr J Med Sci 29: 273-277, 1999." I have read an article entitled “Prevention of recurrences after thyroidectomy in an endemic area with prophylactic levothyroxine use” by Adnan Çalık and coworkers with a great int...

introduction: hypothyroidism is diagnosed by elevated thyroid stimulating hormone (tsh) and normal or decreased serum levels of t4 or t3, and is associated with a wide range of m etabolic abnormalities, including anemia. this clinical study aimed to assess the improvement of anemia in patients with primary hypothyroidism following administration of levothyroxine in iranian population. materials...

PHARMACOTHERAPY IN ADVANCED THYROID CANCER (Abstract): Thyroid cancers are the most common carcinomas of the endocrine system. Their behavior depends of histology, extension of the disease and patients-related factors. Differentiated thyroid cancers arising from follicular epithelium may be cured with combined surgery and radioiodine therapy. In 10-15 % of cases patients may develop metastases ...

OBJECTIVE Thyroid-stimulating hormone (TSH) is a known thyroid growth factor, but the pathogenic role of TSH in thyroid tumorigenesis is controversial. The aim of this study is to examine the relationship between preoperative TSH and differentiated thyroid microcarcinoma (DTMC). DATA SOURCES We searched PubMed, EMBASE, Ovid, Web of Science, and the Cochrane Library from their inception to Mar...