High-throughput RNA-sequencing (RNA-seq) technologies are powerful tools for understanding cellular state. Often, it is of interest to quantify and summarize changes in cell state that occur between experimental or biological conditions. Differential expression typically assessed using univariate tests measure genewise shifts expression. However, these methods largely ignore transcriptional cor...

Excessive salivary contamination of induced sputum samples prevents the satisfactory examination of lower airway inflammation. The effects of salivary contamination on different sputum fluid phase measures and the levels of salivary contamination preventing analysis are not defined. The present study sought to examine this by investigating the effect of increasing salivary contamination on indu...

Induced sputum cell counts provide a relatively noninvasive method to evaluate the presence, type, and degree of inflammation in the airways of the lungs. Their interpretation requires a knowledge of normal values from a healthy population. The objective was to examine the total and differential cell counts in induced sputum from a sample of healthy adults. A total of 118 healthy nonsmoking adu...

Healthcare Delivery Systems are becoming overloaded in developed and developing countries. It is imperative that more efficient and cost effective processes be employed by innovative applications of technology in the delivery system. One such process in Haematology that needs attention is “Generation of report on the Differential Count of Blood”. Most rural centers in India still employ traditi...

In research areas such as decision support systems, one of the crucial features is the ability to automatically explain decisions. However, this ability does not typically play a large role in computer games. Here, I suggest that this situation will change: research on the automatic generation of explanations will have real import for many types of computer games. I discuss four possible ways t...

Young adults in developing countries are attracted and addicted to the habit of smoking due to various reasons. The inhaled smoke from cigarette produces inflammatory reaction in the airways leading to impairment in lung function. Our present study was designed to assess the relationship between the pulmonary function parameters like forced vital capacity (FVC), forced expiratory volume in 1 se...

Total count and differential count of leukocytes or white blood cells (WBC) in blood samples are very important pathological factors for diagnosing a disease. There are not enough pathological infrastructures in the remote places of India and other developing countries. The objective of this work is to design a system, compatible with telemedicine, for automatic calculation of the total count a...

We describe a case of severe leukocytosis caused by leukemic mantle cell lymphoma (MCL), complicated by leukostasis with myocardial infarction in which leukapheresis was used in the initial management. A 73-year-old male presented to the emergency department because of fatigue and thoracic pain. Blood count revealed 630 × 10(9)/L WBC (white blood cells). The electrocardiogram showed ST-elevatio...

We examined RNA-Seq data on 211 biological samples from 24 different Arabidopsis experiments carried out by different labs. We grouped the samples according to tissue types, and in each of the groups, we identified genes that are stably expressed across biological samples, treatment conditions, and experiments. We fit a Poisson log-linear mixed-effect model to the read counts for each gene and ...