In 2010, over 20.3 million vehicles were recalled. Software issues related to automotive controls such as cruise control, anti-lock braking system, traction control and stability control, account for an increasingly large percentage of the overall vehicles recalled. There is a need for new and scalable methods to evaluate automotive controls in a realistic and open setting. We have developed Au...

We propose diagnostics for ARIMA model fitting for time series formed by deleting observations from the data and measuring the change in the estimates of the parameters. The use of leave-one-out diagnostics is a well established tool in regression analysis. We demonstrate the efficacy of observation deletion based diagnostics for ARIMA models, addressing issues special to the time diagnostics b...

Saliva reflects the physiologic state of the body, including emotional, endocrinal, nutritional and metabolic variations, and so can be used to monitor both oral and systemic health. In the past decade, salivary diagnostic approaches have been developed to monitor oral and systemic diseases. Along with these exciting scientific advancements, there is an emerging need to move salivary diagnostic...

BACKGROUND Anecdotal reports from pediatric sites have indicated that some blood glucose meters may display wrong and misleading numbers rather than error indications, when operated in deviation from the instructions for use (IFU), eg by manipulating the strip during the count-down phase. METHODS This study was performed with 60 patients with diabetes (32 female, 28 male, 21 type 1, 39 type 2...

INTRODUCTION Poor healthcare access is a major barrier to receiving antenatal care and a cause of high maternal mortality in South Africa (SA). 'Point-of-care' (POC) diagnostics is a powerful emerging healthcare approach to improve healthcare access. This study focuses on evaluating the accessibility and utility of POC diagnostics for maternal health in rural SA primary healthcare (PHC) clinics...

Companion diagnostics are used to aid clinical decision making to identify patients who are most likely to respond to treatment. They are becoming increasingly important as more new pharmaceuticals receive licensed indications that require the use of a companion diagnostic to identify the appropriate patient subgroup for treatment. These pharmaceuticals have proven benefit in the treatment of s...

This paper describes a case study of model-based diagnostics system development for an aircraft Auxiliary Power Unit (APU) turbine system. The off-line diagnostics algorithms described in the paper work with historical data of a flight cycle. The diagnostics algorithms use detailed turbine engine systems models and fault model knowledge available to an engine manufacturer. The developed algorit...

Employment or Leadership: None declared. Consultant or Advisory Role: P.A. Kavsak, Ortho Clinical Diagnostics; A.R. MacRae, Beckman Coulter; A.S. Jaffe, Beckman Coulter, Siemens, Ortho Diagnostics, Singulex, Nanosphere, Inverness, Critical Diagnostics, GSK, Merck, and Hoffman-LaRoche. Stock Ownership: None declared. Honoraria: P.A. Kavsak, Beckman Coulter. Research Funding: Canadian Institutes ...

We present a new Python/C++ framework, BioLite, for implementing bioinformatics pipelines for NextGeneration Sequencing (NGS) data. BioLite tracks provenance of analyses, automates the collection and reporting of diagnostics (such as summary statistics and plots at intermediate stages), and profiles computational requirements. These diagnostics can be accessed across multiple stages of a pipeli...