Objectives: The cellular immune system mediated by cytotoxic T lymphocytes (CTLs) and Natural killer (NK) cells are thought to play an important role in the ultimate decline of Squamous Intraepithelial Lesions (SILs). In this study, Natural killer and granzyme B (GranzB) positive T-cells were quantitatively evaluated in cervical tissuesamples obtained from women exhibiting invasive cancer (n= 5...

Abstract Modern therapeutic strategies for precancerous cervical intraepithelial neoplasia (CIN) focus on immune-modulatory and cancer vaccination. The local immune status in CIN could influence HPV infection persistence, progression carcinogenesis. We analysed the role of FOXP3+ regulatory T lymphocytes, CD4+ CD8+ lymphocytes I, II III patients with without infection. Sixty-two were enrolled s...

Intimin-conjugated fluorescent beads bind to spleen CD4 T cells and Peyer's patch, mesenteric lymph node, and cecal follicle lymphocytes, with less binding to lamina propria T cells and intraepithelial lymphocytes. Intimin costimulates proliferation of spleen CD4 T cells and cells from organized lymphoid tissues but does not costimulate cells from the lamina propria of normal or inflamed colon.

The origin of autoimmunity leading to the destruction of insulin-producing beta-cells is not known. Several studies suggest that a link exists between the gut immune system and the islets infiltrating lymphocytes. Inflamed pancreatic islets express the same adhesion molecules involved with the homing of gut-associated lymphocytes. The manifestation of autoimmune diabetes in the animal models ca...

A large surface area and continuous exposure to the outside environment through food intake make the intestines an ideal location for the growth and/or entry of pathogenic microorganisms and parasites. It is therefore not surprising that large numbers of lymphocytes are associated with the intestines within specialized gut-associated lymphoid tissues (GALT) and in the intestines themselves (1)....

PURPOSE Postinfectiously irritable bowel syndrome (PI-IBS) develops in 3-30% of individuals with bacterial gastroenteritis. Recent studies demonstrated increases in inflammatory components in gut mucosa of PI-IBS patients even after complete resolution of infection. We aimed to investigate histological changes in colon and rectum of PI-IBS subjects after long term period of infection. MATERIA...