A previous study in our laboratory showed that addition of 150 mM NaCl or KCl into diafiltration water improved the solubility of freshly made milk protein concentrate 80 (MPC80). In the present study, the objectives were (1) to evaluate the solubility of NaCl- or KCl-treated MPC80 samples kept at varying temperatures and then stored for extensive periods at room temperature (21 °C ± 1 °C); and...

purification development for antibodies with affinity, hydrophobic-interaction, and ionexchange chromatography (1). Fahrner et al. discuss the importance of considering the optimal flow rate on protein A affinity chromatography and suggest that higher flow rates will reduce process time significantly without significantly affecting process capacity (2). Notwithstanding these good publications, ...

Separation of polyphenolic phytochemical compounds from their mixtures with sugars is necessary to produce an added-value sugar-reduced extract with high biological activity from fruit juice processing industry waste streams. The separation characteristics of a binary mixture of rutin and glucose using a Pellicon-2 regenerated cellulose ultrafiltration membrane with an area of 0.1 m(2) having n...

Introduction: Inorganic mercury intoxication is rare and usually the result of occupational exposure, suicide attempt or accident. This article presents the case of acute poisoning due to peritoneal lavage with mercury bichloride. Case report: A 30 year old woman was operated in order to remove a teratoma from her right ovary. On the second postoperative day she presented ileus, renal failure a...

Sir, Extracorporeal membrane oxygenation (ECMO) is a supportive therapy and definitive management often relies on adequate drug therapy aimed at reversing the underlying cause of cardiac and/or respiratory failure. Despite this, a paucity of data exists describing the impact of ECMO on pharmacokinetics (PK) and antibiotic dosing requirements. By default, clinicians prescribe standard doses to t...

The objective of this work was to determine if concentration of milk using ultrafiltration (in the absence of diafiltration) affects the physico-chemical properties of the casein micelles. The milk, once concentrated, was brought back to its original concentration and the physico-chemical properties as well as its susceptibility to rennet induced gelation were assessed. Although much is underst...

UNLABELLED We report the synthesis and preliminary biologic testing of a synthetic macromolecule, (99m)Tc-diethylenetriaminepentaacetic acid (DTPA)--mannosyl-dextran, for sentinel node detection. METHODS Synthesis started with a 2-step process that attaches a high density of amino-terminated leashes to a dextran backbone. Allyl-bromide was reacted with pharmaceutical-grade dextran to yield al...

Size and geometric control of nanomaterials are important to the discovery of intrinsic size/shape dependent properties and bottom up approaches for the fabrication of functional nanodevices. Two general strategies have been employed to create size-uniform nanocrystals. One method is direct particle size control during synthesis by adjusting growth parameters; 7–9] the other is post-synthesis s...