the aim of the present study was to investigate the effect of endurance training on syd gene expression in motor neurons of rats with diabetic neuropathy. 12 wistar male rats were randomly assigned to 3 groups (each group 4 subjects): diabetic trained (dt), diabetic untrained (dc) and healthy control (hc). two weeks after stz injection to induce diabetes, diabetic neuropathy was demonstrated by...

objective(s): this study was to investigate the potential anti-diabetic effects of alcoholic extract of salvia hydrangea in rats. materials and methods:thirty five male wistar rats were divided into five groups namely non-diabetic control, diabetic control, and three experimental diabetic that received either salvia hydrangea extract for 21 days at the doses of 100 and 200 or glibenclamide at t...

The efficacy of concomitant administration metformin and Cnidoscolus aconitifolius (Chaya) teas in type 2 diabetic rat models was evaluated. Diabetic rats were treated for 28 days with infusions green (GTC) black (BTC) chaya teas. Total phenol flavonoid contents, as the antioxidant capacities tea infusions, assessed. Fasting blood glucose (FBG), lipid profile markers hepatic renal functions GTC...

The mechanism of liver glycogen synthesis after refeeding has been investigated in diabetic rats, diabetic insulin-treated rats, and in control rats fasted for 48 h. The accumulation of liver glycogen was the same in diabetic rats and in control rats after 2 h of feeding, but did not proceed any further in the diabetic group during the next 2 h. Insulin-treated diabetic rats synthesized five ti...

Levels of red cell, serum acid, and alkaline phosphatases, serum amylase, alanine and aspartate transferase and bilirubin were examined in streptozotocin-induced diabetic rats treated with garlic oil and compared with the corresponding levels in diabetic control rats, normal rats and normal rats on garlic oil. Values of tissue amylase and total protein were also assessed from the pancreas, live...

conclusions compared with acarbose or metformin monotherapy, the addition of acarbose to metformin had superior antihyperglycemia efficacy and provided an efficacious and safe alternative for the treatment of type 2 diabetic rats. acarbose/metformin reduced the fasting blood glucose and glycated hemoglobin without significant changes in serum visfatin levels. background diabetes mellitus is a c...

Background: Several lines of evidence suggest that oxidized LDL (Ox-LDL) scavenger receptors play a crucial role in the genesis and progression of diabetic atherosclerosis. This study aimed to elucidate the effect of vitamin D3 on gene expression of lectin-like oxidized LDL receptor-1 (LOX-1), scavenger receptor-A (SR-A), Cluster of Differentiation 36 (CD36), and Cluster of Differentiation 68 (...

Pain is a complex process in the central nervous system (CNS). Several factors can alter the pain threshold and insulin is one of them which is produced by the beta cells of pancreas and capable of crossing blood-brain barrier. The aim of this study was to evaluate the effects of intra-cerebroventricular (ICV) injection of insulin on the pain response to formalin in short-term induced diabetic ...

Erectile dysfunction is caused due to neuropathy, resulting from a high oxidative stress, in this way treatment with antioxidants may be promising. Aim of work was investigate the effects administration 2% L-glutamine and 1% L-glutathione on penile tissue diabetic rats analyzing nerve fibers that expressing Nitric Oxide Synthase Neuronal (nNOS). Forty-eight male Wistar distributed into six grou...

To consider potentially new hypoglycemic and antihyperlipidemic sources, aqueous extracts from four Korean medicinal plants, Chrysanthemum coronarium, Dioscorea batatas, Morus alba, Citrus unshiu, were investigated in alloxan-induced diabetic rats. To induce diabetes, 36 rats were administered alloxan orally (120 mg/kg body weight) for 2 weeks and among those 6 rats were used as a diabetic cont...