2-DG triggers glucose deprivation without altering other nutrients or metabolic pathways and then activates autophagy via activation of AMPK and endoplasmic reticulum (ER) stress. We investigated whether 2-DG reduced intracellular insulin increased by melatonin via autophagy/EDC3 in insulinoma INS-1E cells. p-AMPK and GRP78/BiP level were significantly increased by 2-DG in the presence/absence ...

Strip loins from 236 carcasses from crossbred yearling steers were collected on each of 2 slaughter dates (slaughter 1 or 2) to determine the effects of feeding corn or sorghum distillers grains (DG) on beef color, fatty acid profiles, lipid oxidation, tenderness, and sensory attributes. Dietary treatments consisted of a steam-flaked corn (SFC) diet without (control) or with 15% (DM basis) corn...

The need for energy and environmental sustainability drives the adoption of renewable systems to reduce greenhouse gas emissions. Efficient planning sources is crucial a reliable distribution network. This article solves optimal allocation hybrid (i.e., Renewable Distribution Generators (RDGs) Battery Energy Storage System (BESS)) problem, aiming minimize annual loss investment costs simultaneo...

Distributed generation (DG) and capacitor bank (CB) allocation in distribution systems (DS) has the potential to enhance overall system performance of radial (RDS) using a multiobjective optimization technique. The benefits CB DG injection RDS greatly depend on selecting suitable number CBs/DGs their volume along with finest location. This work proposes applying hybrid enhanced grey wolf optimi...

Power loss and voltage uncertainty are the major issues prevalently faced in design of distribution systems. But such can be resolved through effective usage networking reconfiguration that has a combination Distributed Generation (DG) units from networks. In this point view, optimal placement sizing DGs ways to boost performance power The optimum allocation resolves various problems namely, lo...

Introduction. To minimise power loss, maintain the voltage within acceptable range, and improve quality in distribution networks, reconfiguration optimal distributed generation placement are presented. Power flow analysis advanced optimization techniques that can handle significant combinatorial problems must be used network investigations. The approach to depends on size of network. Our method...

Our understanding of mechanisms that regulate the differentiation of specific classes of synapses is limited. Here, we investigate the formation of synapses between hippocampal dentate gyrus (DG) neurons and their target CA3 neurons and find that DG neurons preferentially form synapses with CA3 rather than DG or CA1 neurons in culture, suggesting that specific interactions between DG and CA3 ne...

M(1)dG (3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one) lesions are mutagenic in bacterial and mammalian cells, leading to base substitutions (mostly M(1)dG to dT and M(1)dG to dA) and frameshift mutations. M(1)dG is produced endogenously through the reaction of peroxidation products, base propenal or malondialdehyde, with deoxyguanosine residues in DNA. The mutagenic...

Poly(dG-dC).poly(dG-dC) and poly(dG).poly(dC) were modified by treatment with N-acetoxy-N-2-acetylaminofluorene, and their conformations were examined by circular dichroism and susceptibility to nuclease S1 digestion. A sample of poly(dG-dC).poly(dG-dC) modified to an extent of 28% with acetylaminofluorene (AAF) at the C(8) position of the deoxyguanosine residues showed a circular dichroism spe...

The expression of homosynaptic long-term depression (LTD) is thought to mediate a crucial role in sustaining memory function. Our in vivo investigations of LTD expression at lateral (LPP) and medial perforant path (MPP) synapses in the dentate gyrus (DG) corroborate prior demonstrations that PP-DG LTD is difficult to induce in intact animals. In freely moving animals, LTD expression occurred in...