Our goal was to determine whether chlorpyrifos oxon, dichlorvos, diisopropylXuorophosphate (DFP), and sarin covalently bind tohuman albumin. Human albumin or plasma was treated with organophosphorus (OP) agent at alkaline pH, digested with pepsin at pH2.3, and analyzed by matrix-assisted laser desorption/ionization time-of-Xight (MALDI-TOF) mass spectrometry. Two singly chargedpeaks...

Brain iron accumulation has been associated with inciting the generation of oxidative stress in a host of chronic neurological diseases, including Parkinson's disease. Using the catecholaminergic neurotoxin 6-hydroxydopamine to lesion cellular dopaminergic pathways as a model of Parkinson's disease in culture, a selection of 1-hydroxypyridin-2-one (1,2-HOPO) metal chelators were synthesized and...

The purpose of this paper is an optimal control problem of temperature using the Newton based method and the finite element method. This method is based on the first and second order adjoint technique allowing to obtained a better approximation to the Newton line search direction. The formulation is based on the optimal control theory in which the performance function is expressed by the comput...

The extensive use of organophosphates (OPs) is an ongoing environmental health concern due to multiple reports of OP-related neurologic abnormalities. The mechanism of the acute toxicity of OPs has been attributed to inhibition of acetylcholinesterase (AChE), but there is growing evidence that this may not account for all the long-term neurotoxic effects of OPs. In previous experiments (using e...

A new rank-two variable-metric method is derived using Greenstadt's variational approach [Math. Comp., this issue]. Like the Davidon-Fletcher-Powell (DFP) variable-metric method, the new method preserves the positive-definiteness of the approximating matrix. Together with Greenstadt's method, the new method gives rise to a one-parameter family of variable-metric methods that includes the DFP an...

AIMS To evaluate the effectiveness of management of diabetic foot problems (DFP) by the National University Hospital (NUH) Multidisciplinary Diabetic Foot Team combined with a clinical pathway in terms of average length of stay (ALOS), readmission rates, hospitalisation cost per patient, major reamputation rate, and complication rate. METHODS 939 patients admitted to the Department of Orthopa...

Chemical modification and site-specific mutagenesis approaches were used in this study to identify the active site serine residue of pancreatic cholesterol esterase. In the first approach, purified porcine pancreatic cholesterol esterase was covalently modified by incubation with [3H]diisopropylfluorophosphate (DFP). The radiolabeled cholesterol esterase was digested with CNBr, and the peptides...

Morpho-physiological and biochemical changes in developing cucumber (Cucumis sativus L) seeds were monitored under both open field (E1) protected environments (E2) during 2019 at ICAR-IARI, New Delhi. Fruits developed from hand pollinated flowers, Pusa Barkha Uday varieties harvested five-day intervals. The environment influenced days to maturity development of fruit and/or seed. Irrespective v...

The BFGS update and the DFP update perhaps are respectively the most successful Hessian and inverse Hessian approximations for unconstrained minimization problems This paper describes a geometric meaning of these updates understood from the Wedderburn rank one reduction formula

The rapidly increasing number of internet things (IoT) and non-IoT devices has imposed new security challenges to network administrators. Accurate device identification in the increasingly complex structures is necessary. In this paper, a fingerprinting (DFP) method been proposed for identification, based on digital footprints, which use communication over network. A subset nine features have s...