Background: Thermal stability (TS) is a part of the BCG vaccine characterization by which the consistency of process in BCG vaccine production could be confirmed. To enhance the TS of the vaccine, some prevalent stabilizers in different concentrations were added to the final formulation of BCG bulk prior to Freeze-drying process. We found a formulation more effective than the current stabilizer...

Corneal decellularization has become an increasingly popular technique for generating scaffolds for corneal regeneration. Most decellularization procedures result in tissue swelling, thus limiting their application. Here, the use of a polysaccharide, dextran, to reduce swelling and conserve the native corneal structure during decellularization was investigated. Corneas were treated with 1% Trit...

UNLABELLED Hexachlorobenzene-induced porphyria is iron dependent and characterized by the decreased activity of uroporphyrinogen decarboxylase and the accumulation of porphyrins in the liver. To examine the relationship between iron and porphyrins in liver tissue, we performed a biochemical and morphological (histological, ultrastructural and morphometrical) study in the livers of C57BL/10 mice...

The Effect of Different Ozone Concentrations on the Expression β-catenin and HIF-I Genes in Colon Tissue BALB/c Mice Treated with Azoxymethane/dextran Sodium Sulfate

Intramuscular dexamethasone combined with intravenous low-molecular-weight dextran (dextran 40) was compared with placebo in 40 patients with acute ischaemic cerebral infarction. A double-blind procedure was used. Dexamethasone was given for up to 14 days and dextran 40 for up to three days after the infarction. A weighted scoring system was used to evaluate neurological state and mobility. The...

Intravenous administration of Dextran 40 exerts an antithrombotic effect on platelets, endothelium and red blood cells by reducing aggregation and adhesiveness. Intravascular clots are less likely to form in the presence of dextran. This property of dextran has made it useful as a prophylactic agent for deep venous thrombosis (DVT) in surgical patients. It also is used to maintain patency of ve...