Introduction: Surfactant is an important treatment modality in preterm babies with respiratory distress syndrome leading to decrease mortality, morbidity and cost of treatment. Experiences on surfactant therapy Nepal are scarce. This study was conceptualised find the use immediate outcome a tertiary care hospital Nepal. Methods: A cross-sectional done who received over period five years at neon...

introduction: doxorubicin is frequently used for treatment of several types of cancer. doxorubicin cardiac toxicity has limited the use of this drug. corticosteroids may prevent doxorubicin induced cardiotoxicity. therefore the aim of this study was to evaluate mouse embryonic stem cells derived cardiomyocytes as a model to evaluate the effect of doxorubicin and dexamethasone. methods: mouse em...

dexamethasone induces thymic atrophy and thymocyte apoptosis. in the present study histological and ultrastructural changes which occur in the thymus of the mouse (balb/c) following treatment with high (20 mg/kg) and low (8 mg/kg) doses of dexamethasone were investigated. in low dose treated mice, apoptotic cells were observed focally and localized mainly in thymic nurse cells (t.n.c.). a zone ...

Transgenic C57BL/6 mice expressing human serum amyloid P component (HuSAP) are resistant to Shiga toxin 2 (Stx2) at dosages that are lethal in HuSAP-negative wild-type mice. However, it is well established that Stx2 initiates extra-intestinal complications such as the haemolytic-uremic syndrome despite the presence of HuSAP in human sera. We now demonstrate that co-administering purified Escher...

in an analytical, cohort type study, medical and obstetrical complications of 500 pregnant women over age 35 were compared with 500 younger pregnant women during 3 past years (1994-1997). 7he incidence of complications were significantly increased in pregnant women over age 35 (p

neurologic and psychologic complications are usually related to drug toxicity, infections or symptoms induced by deterioration of renal allograft function. metabolic encephalopathy, hypertensive encephalopathy, cerebrovascular events, and new-onset seizures have all been reported in organ-transplant recipients. infections can be caused by listeria, cryptococcus, nocardia, aspergillus and mucor....

introduction: chemotherapeutic drugs used to treat cancer may cause nausea and emesis by inducing the release of 5-hydroxytryptamine (5-ht) in the small intestine. blockage of 5-ht 3 receptors in the small intestine by 5-ht 3 receptor antagonists might prevent the nausea and vomiting associated with chemotherapy for cancer. the aim of this study was to compare the efficacy and tolerability of t...

Introduction: Febrile seizures are the most common seizure disorder in childhood and its prevalence is estimated to be 2 to 5 percent. There is a relationship between the use of corticosteroids and seizures. This study investigated the effects of dexamethasone pretreatment on convulsive behavior caused by hyperthermia. Methods: In this study, 24 rats aged 19-20 days were divided into 3 group...

in this study, the effects of separate and combined intraperitoneal (ip) injections of histidine and dexamethasone were investigated on local inflammation in rats. local inflammation was induced by subcutaneous (sc) injection of histamine (100 μl, 0.1%) in ventral surface of right hind paw. the thickness of paw was measured at 30 min before and 30, 60, 90, 120, 150 and 180 min after injection o...